دورية أكاديمية
Pupillometry to differentiate idiopathic hypersomnia from narcolepsy type 1
| العنوان: | Pupillometry to differentiate idiopathic hypersomnia from narcolepsy type 1 |
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| المؤلفون: | Rach, Héloïse, Reynaud, Eve, Kilic-Huck, Ulker, Ruppert, Elisabeth, Comtet, Henri, Roy de Belleplaine, Virginie, Fuchs, Fanny, Van Someren, Eus J.W., Geoffroy, Pierre A., Bourgin, Patrice |
| المصدر: | Rach , H , Reynaud , E , Kilic-Huck , U , Ruppert , E , Comtet , H , Roy de Belleplaine , V , Fuchs , F , Van Someren , E J W , Geoffroy , P A & Bourgin , P 2023 , ' Pupillometry to differentiate idiopathic hypersomnia from narcolepsy type 1 ' , Journal of Sleep Research , vol. 32 , no. 5 , e13885 , pp. 1-11 . https://doi.org/10.1111/jsr.13885Test |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | biomarkers, idiopathic hypersomnia, melanopsin-mediated pupil response, narcolepsy type 1, pupil diameter, pupillometry |
| الوصف: | Idiopathic hypersomnia is poorly diagnosed in the absence of biomarkers to distinguish it from other central hypersomnia subtypes. Given that light plays a main role in the regulation of sleep and wake, we explored the retinal melanopsin-based pupil response in patients with idiopathic hypersomnia and narcolepsy type 1, and healthy subjects. Twenty-seven patients with narcolepsy type 1 (women 59%, 36 ± 11.5 years old), 36 patients with idiopathic hypersomnia (women 83%, 27.2 ± 7.2 years old) with long total sleep time (> 11/24 hr), and 43 controls (women 58%, 30.6 ± 9.3 years old) were included in this study. All underwent a pupillometry protocol to assess pupil diameter, and the relative post-illumination pupil response to assess melanopsin-driven pupil responses in the light non-visual input pathway. Differences between groups were assessed using logistic regressions adjusted on age and sex. We found that patients with narcolepsy type 1 had a smaller baseline pupil diameter as compared with idiopathic hypersomnia and controls (p < 0.05). In addition, both narcolepsy type 1 and idiopathic hypersomnia groups had a smaller relative post-illumination pupil response (respectively, 31.6 ± 13.9% and 33.2 ± 9.9%) as compared with controls (38.7 ± 9.7%), suggesting a reduced melanopsin-mediated pupil response in both types of central hypersomnia (p < 0.01). Both narcolepsy type 1 and idiopathic hypersomnia showed a smaller melanopsin-mediated pupil response, and narcolepsy type 1, unlike idiopathic hypersomnia, also displayed a smaller basal pupil diameter. Importantly, we found that the basal pupil size permitted to well discriminate idiopathic hypersomnia from narcolepsy type 1 with a specificity = 66.67% and a sensitivity = 72.22%. Pupillometry may aid to multi-feature differentiation of central hypersomnia subtypes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vu.nl/en/publications/eddf5f72-44fe-4300-a7b7-e217bbffa858Test |
| DOI: | 10.1111/jsr.13885 |
| الإتاحة: | https://doi.org/10.1111/jsr.13885Test https://research.vu.nl/en/publications/eddf5f72-44fe-4300-a7b7-e217bbffa858Test https://hdl.handle.net/1871.1/eddf5f72-44fe-4300-a7b7-e217bbffa858Test http://www.scopus.com/inward/record.url?scp=85151918463&partnerID=8YFLogxKTest http://www.scopus.com/inward/citedby.url?scp=85151918463&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2E0CA697 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jsr.13885 |
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