دورية أكاديمية
Delayed Influenza Treatment in Children With False-Negative Rapid Antigen Test: A Retrospective Single-Center Study in Korea 2016-2019
| العنوان: | Delayed Influenza Treatment in Children With False-Negative Rapid Antigen Test: A Retrospective Single-Center Study in Korea 2016-2019 |
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| المساهمون: | Ji Young Lee, Seung Hwan Baek, Jong Gyun Ahn, Seo Hee Yoon, Moon Kyu Kim, Soo Yeon Kim, Kyung Won Kim, Myung Hyun Sohn, Ji-Man Kang, Kang, Ji-Man |
| بيانات النشر: | 대한의학회(The Korean Academy of Medical Sciences) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Antigens, Viral / blood, Antiviral Agents / therapeutic use, Child, Preschool, Cost-Benefit Analysis, False Negative Reactions, Female, Humans, Infant, Influenza, Human / blood, Human / diagnosis, Human / drug therapy, Human / economics, Male, Orthomyxoviridae / immunology, Republic of Korea, Retrospective Studies, Time-to-Treatment, Emergency Department, Oseltamivir, Point-of-Care Testing, Polymerase Chain Reaction |
| الوصف: | Background: We aimed to examine the delay in antiviral initiation in rapid antigen test (RAT) false-negative children with influenza virus infection and to explore the clinical outcomes. We additionally conducted a medical cost-benefit analysis. Methods: This single-center, retrospective study included children (aged < 10 years) with influenza-like illness (ILI), hospitalized after presenting to the emergency department during three influenza seasons (2016-2019). RAT-false-negativity was defined as RAT-negative and polymerase chain reaction-positive cases. The turnaround time to antiviral treatment (TAT) was from the time when RAT was prescribed to the time when the antiviral was administered. The medical cost analysis by scenarios was also performed. Results: A total of 1,430 patients were included, 7.5% were RAT-positive (n = 107) and 2.4% were RAT-false-negative (n = 20). The median TAT of RAT-false-negative patients was 52.8 hours, significantly longer than that of 4 hours in RAT-positive patients (19.2-100.1, P < 0.001). In the multivariable analysis, TAT of ≥ 24 hours was associated with a risk of severe influenza infection and the need for mechanical ventilation (odds ratio [OR], 6.8, P = 0.009 and OR, 16.2, P = 0.033, respectively). The medical cost varied from $11.7-187.3/ILI patient. Conclusion: Antiviral initiation was delayed in RAT-false-negative patients. Our findings support the guideline that children with influenza, suspected of having severe or progressive infection, should be treated immediately. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1011-8934 1598-6357 |
| العلاقة: | JOURNAL OF KOREAN MEDICAL SCIENCE; J01517; OAK-2022-02032; https://ir.ymlib.yonsei.ac.kr/handle/22282913/188482Test; T202201303; JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.37(1) : e3, 2022-01 |
| DOI: | 10.3346/jkms.2022.37.e3 |
| الإتاحة: | https://doi.org/10.3346/jkms.2022.37.e3Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/188482Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.2C8F0DFE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10118934 15986357 |
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| DOI: | 10.3346/jkms.2022.37.e3 |