صورة
Fig 7 -
| العنوان: | Fig 7 - |
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| المؤلفون: | Mubashir Aziz, Muhammad Sarfraz, Muhammad Khurrum Ibrahim, Syeda Abida Ejaz, Tasneem Zehra, Hanan A. Ogaly, Mosab Arafat, Fatimah A. M. Al-Zahrani, Chen Li |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, significant global cause, potent bioactive agents, particularly potent candidate, one strategic avenue, lactate dehydrogenase release, imparting significant insights, amidst ongoing efforts, employed computational techniques, computational analyses suggest, molecular dynamics simulations, including molecular docking, 3 activity assays, hydroxyacetyl )- 4, 6s )- 4, promising anticancer candidates, via caspase 3, study &# 8217, knowledge holds potential, demonstrated marked efficacy |
| الوصف: | Cancer stands as a significant global cause of mortality, predominantly arising from the dysregulation of key enzymes and DNA. One strategic avenue in developing new anticancer agents involves targeting specific proteins within the cancer pathway. Amidst ongoing efforts to enhance the efficacy of anticancer drugs, a range of crucial medications currently interact with DNA at the molecular level, exerting profound biological effects. Our study is driven by the objective to comprehensively explore the potential of two compounds: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione (A01) and 5-fluoro-1H-pyrimidine-2,4-dione (A02). These compounds have demonstrated marked efficacy against breast and cervical cancer cell lines, positioning them as promising anticancer candidates. In our investigation, A01 has emerged as a particularly potent candidate, with its potential bolstered by corroborative evidence from lactate dehydrogenase release and caspase-3 activity assays. On the other hand, A02 has exhibited remarkable anticancer potential. To further elucidate their molecular mechanisms and interactions, we employed computational techniques, including molecular docking and molecular dynamics simulations. Notably, our computational analyses suggest that the A01-DNA complex predominantly interacts via the minor groove, imparting significant insights into its mechanism of action. While earlier studies have also highlighted the anticancer activity of A01, our research contributes by providing a deeper understanding of its binding mechanisms through computational investigations. This knowledge holds potential for designing more effective drugs that target cancer-associated proteins. These findings lay a robust groundwork for future inquiries and propose that derivatives of A01 could be synthesized as potent bioactive agents for cancer treatment. By elucidating the distinctive aspects of our study’s outcomes, we address the ... |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Fig_7_-/24890233Test |
| DOI: | 10.1371/journal.pone.0292455.g007 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0292455.g007Test https://figshare.com/articles/figure/Fig_7_-/24890233Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.2C69B3FF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0292455.g007 |
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