دورية أكاديمية
Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia
| العنوان: | Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia |
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| المؤلفون: | André J Tremblay, Benoît Lamarche, Jean-Charles Hogue, Patrick Couture |
| المصدر: | Journal of Lipid Research, Vol 50, Iss 7, Pp 1463-1471 (2009) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2009 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Apolipoprotein B-48, apolipoprotein B-100, cholesterol absorption and synthesis, gas chromatography/mass spectrometry, intestine, kinetic, Biochemistry, QD415-436 |
| الوصف: | Sixteen hyperlipidemic men were enrolled in a randomized, placebo-controlled, double-blind, cross-over study to evaluate the effect of ezetimibe 10 mg and simvastatin 40 mg, coadministered and alone, on the in vivo kinetics of apolipoprotein (apo) B-48 and B-100 in humans. Subjects underwent a primed-constant infusion of a stable isotope in the fed state. The coadministration of simvastatin and ezetimibe significantly reduced plasma concentrations of cholesterol (−43.0%), LDL-C (−53.6%), and triglycerides (−44.0%). Triglyceride-rich lipoproteins (TRL) apoB-48 pool size (PS) was significantly decreased (−48.9%) following combination therapy mainly through a significant reduction in TRL apoB-48 production rate (PR) (−38.0%). The fractional catabolic rate (FCR) of VLDL and LDL apoB-100 were significantly increased with all treatment modalities compared with placebo, leading to a significant reduction in the PS of these fractions. We also observed a positive correlation between changes in TRL apoB-48 PS and changes in TRL apoB-48 PR (r = 0.85; P < 0.0001) with combination therapy. Our results indicate that treatment with simvastatin plus ezetimibe is effective in reducing plasma TRL apoB-48 levels and that this effect is most likely mediated by a reduction in the intestinal secretion of TRL apoB-48. Our study also indicated that the reduction in LDL-C concentration following combination therapy is mainly driven by an increase in FCR of apoB-100 containing lipoproteins. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-02-222752-4 0-02-222752-0 |
| تدمد: | 0022-2275 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S0022227520307938Test; https://doaj.org/toc/0022-2275Test; https://doaj.org/article/ffd28ce249ef434fb58ec3dd9a4f4558Test |
| DOI: | 10.1194/jlr.P800061-JLR200 |
| الإتاحة: | https://doi.org/10.1194/jlr.P800061-JLR200Test https://doaj.org/article/ffd28ce249ef434fb58ec3dd9a4f4558Test |
| رقم الانضمام: | edsbas.2C44178B |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780022227524 0022227520 |
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| تدمد: | 00222275 |
| DOI: | 10.1194/jlr.P800061-JLR200 |