دورية أكاديمية
67 Double impact: hypophosphatemic rickets and vitamin D intoxication
| العنوان: | 67 Double impact: hypophosphatemic rickets and vitamin D intoxication |
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| المؤلفون: | Boutrid, N, Rahmoune, H, Boutrid, H, Bioud, B, Amrane, M |
| المصدر: | Rheumatology ; volume 61, issue Supplement_2 ; ISSN 1462-0324 1462-0332 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology (medical), Rheumatology |
| الوصف: | Background Vitamin D prevents deficiency rickets, but its prescription must be weighed carefully! Objective We report a rare case of iatrogenic toxic hypervitaminosis D in a child with vitamin D resistant rickets…! Methods We admitted a two-year-old girl, presenting signs of rickets resistant to the usual then therapeutic doses of vitamin D3. Vitamin D2 in oral suspension is then ordered in addition, for a few weeks until the onset of hearing loss motivating her hospitalization in pediatrics. Results Biological and radiological explorations revealed renal failure with threatening arterial hypertension, as well as diffuse and severe arteriosclerosis on Doppler signal. Eviction (stopping vitamin D in all its forms), symptomatic and conservative management by (converting-enzyme inhibitors) and hydration allowed a progressive blood pressure normalisation, arteriosclerosis disappearance (undetected by Doppler signal and by angio-scan) along with a gradual normalising of the kidney function; all this over a period of 2 years The girl actually had hypophosphatemic rickets, and oral phosphorus (syrup) was also prescribed Conclusion Vitamin D is potentially toxic with sometimes severe renal risks (lithiasis, nephrocalcinosis), and hypercalcemia might be severe, especially if renal function is impaired. Blindly treating any rickets with vitamin D can be adventurous and might expose the child to serious morbidity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/rheumatology/keac496.063 |
| الإتاحة: | https://doi.org/10.1093/rheumatology/keac496.063Test https://academic.oup.com/rheumatology/article-pdf/61/Supplement_2/keac496.063/46356275/keac496.063.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.2C2446DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keac496.063 |
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