التفاصيل البيبلوغرافية
| العنوان: |
Genetic evidence for causal relationships between maternal obesity-related traits and birth weight |
| المؤلفون: |
Tyrrell, J. (Jessica), Richmond, R. C. (Rebecca C.), Palmer, T. M. (Tom M.), Feenstra, B. (Bjarke), Rangarajan, J. (Janani), Metrustry, S. (Sarah), Cavadino, A. (Alana), Paternoster, L. (Lavinia), Armstrong, L. L. (Loren L.), De Silva, N. M. (N. Maneka G.), Wood, A. R. (Andrew R.), Horikoshi, M. (Momoko), Geller, F. (Frank), Myhre, R. (Ronny), Bradfield, J. P. (Jonathan P.), Kreiner-Moller, E. (Eskil), Huikari, V. (Ville), Painter, J. N. (Jodie N.), Hottenga, J.-J. (Jouke-Jan), Allard, C. (Catherine), Berry, D. J. (Diane J.), Bouchard, L. (Luigi), Das, S. (Shikta), Evans, D. M. (David M.), Hakonarson, H. (Hakon), Hayes, M. G. (M. Geoffrey), Heikkinen, J. (Jani), Hofman, A. (Albert), Knight, B. (Bridget), Lind, P. A. (Penelope A.), McCarthy, M. I. (Mark I.), McMahon, G. (George), Medland, S. E. (Sarah E.), Melbye, M. (Mads), Morris, A. P. (Andrew P.), Nodzenski, M. (Michael), Reichetzeder, C. (Christoph), Ring, S. M. (Susan M.), Sebert, S. (Sylvain), Sengpiel, V. (Verena), Sorensen, T. I. (Thorkild I. A.), Willemsen, G. (Gonneke), de Geus, E. J. (Eco J. C.), Martin, N. G. (Nicholas G.), Spector, T. D. (Tim D.), Power, C. (Christine), Järvelin, M.-R. (Marjo-Riitta), Bisgaard, H. (Hans), Grant, S. F. (Struan F. A.), Nohr, E. A. (Ellen A.), Jaddoe, V. W. (Vincent W.), Jacobsson, B. (Bo), Murray, J. C. (Jeffrey C.), Hocher, B. (Berthold), Hattersley, A. T. (Andrew T.), Scholtens, D. M. (Denise M.), Smith, G. D. (George Davey), Hivert, M.-F. (Marie-France), Felix, J. F. (Janine F.), Hypponen, E. (Elina), Lowe, W. L. (William L., Jr.), Frayling, T. M. (Timothy M.), Lawlor, D. A. (Debbie A.), Freathy, R. M. (Rachel M.) |
| بيانات النشر: |
American Medical Association |
| سنة النشر: |
2016 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| الوصف: |
Importance: Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain. Objective: To test for genetic evidence of causal associations of maternal body mass index (BMI) and related traits with birth weight. Design, Setting, and Participants: Mendelian randomization to test whether maternal BMI and obesity-related traits are potentially causally related to offspring birth weight. Data from 30 487 women in 18 studies were analyzed. Participants were of European ancestry from population- or community-based studies in Europe, North America, or Australia and were part of the Early Growth Genetics Consortium. Live, term, singleton offspring born between 1929 and 2013 were included. Exposures: Genetic scores for BMI, fasting glucose level, type 2 diabetes, systolic blood pressure (SBP), triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, vitamin D status, and adiponectin level. Main Outcome and Measure: Offspring birth weight from 18 studies. Results: Among the 30 487 newborns the mean birth weight in the various cohorts ranged from 3325 g to 3679 g. The maternal genetic score for BMI was associated with a 2-g (95% CI, 0 to 3 g) higher offspring birth weight per maternal BMI-raising allele (P = .008). The maternal genetic scores for fasting glucose and SBP were also associated with birth weight with effect sizes of 8 g (95% CI, 6 to 10 g) per glucose-raising allele (P = 7 × 10−14) and −4 g (95% CI, −6 to −2g) per SBP-raising allele (P = 1×10−5), respectively. A 1-SD ( ≈ 4 points) genetically higher maternal BMI was associated with a 55-g higher offspring birth weight (95% CI, 17 to 93 g). A 1-SD ( ≈ 7.2 mg/dL) genetically higher maternal fasting glucose concentration was associated with 114-g higher offspring birth weight (95% CI, 80 to 147 g). However, a 1-SD ( ≈ 10 mm Hg) genetically higher maternal SBP was ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2019050914900Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © 2016, American Medical Association. |
| رقم الانضمام: |
edsbas.2BCDF977 |
| قاعدة البيانات: |
BASE |
