دورية أكاديمية
Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial
| العنوان: | Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial |
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| المؤلفون: | Lemiale, Virginie, Mokart, Djamel, Resche-Rigon, Matthieu, Pène, Frédéric, Mayaux, Julien, Faucher, Etienne, Nyunga, Martine, Girault, Christophe, Perez, Pierre, Guitton, Christophe, Ekpe, Kenneth, Kouatchet, Achille, Théodose, Igor, Benoit, Dominique, Canet, Emmanuel, Barbier, François, Rabbat, Antoine, Bruneel, Fabrice, Vincent, François, Klouche, Kada, Loay, Kontar, Mariotte, Eric, Bouadma, Lila, Moreau, Anne-Sophie, Seguin, Amélie, Meert, Anne-Pascale, Reignier, Jean, Papazian, Laurent, Mehzari, Ilham, Cohen, Yves, Schenck, Maleka, Hamidfar, Rebecca, Darmon, Michael, Demoule, Alexandre, Chevret, Sylvie, Azoulay, Elie |
| المصدر: | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION ; ISSN: 0098-7484 |
| سنة النشر: | 2015 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, CRITICALLY-ILL PATIENTS, INTENSIVE-CARE-UNIT, PROSPECTIVE MULTICENTER DATA, DISTRESS-SYNDROME, MECHANICAL VENTILATION, ONCOLOGY PATIENTS, HEMATOLOGY, SURVIVAL, CANCER, MALIGNANCIES |
| الوصف: | IMPORTANCE: Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure. However, its effectiveness for this indication remains unclear. OBJECTIVE: To determine whether early noninvasive ventilation improved survival in immunocompromised patients with nonhypercapnic acute hypoxemic respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized trial conducted among 374 critically ill immunocompromised patients, of whom 317 (84.7%) were receiving treatment for hematologic malignancies or solid tumors, at 28 intensive care units (ICUs) in France and Belgium between August 12, 2013, and January 2, 2015. INTERVENTIONS: Patients were randomly assigned to early noninvasive ventilation (n = 191) or oxygen therapy alone (n = 183). MAIN OUTCOMES AND MEASURES: The primary outcome was day-28 mortality. Secondary outcomes were intubation, Sequential Organ Failure Assessment score on day 3, ICU-acquired infections, duration of mechanical ventilation, and ICU length of stay. RESULTS: At randomization, median oxygen flow was 9 L/min (interquartile range, 5-15) in the noninvasive ventilation group and 9 L/min (interquartile range, 6-15) in the oxygen group. All patients in the noninvasive ventilation group received the first noninvasive ventilation session immediately after randomization. On day 28 after randomization, 46 deaths (24.1%) had occurred in the noninvasive ventilation group vs 50 (27.3%) in the oxygen group (absolute difference, -3.2 [95% CI, -12.1 to 5.6]; P = .47). Oxygenation failure occurred in 155 patients overall (41.4%), 73 (38.2%) in the noninvasive ventilation group and 82 (44.8%) in the oxygen group (absolute difference, -6.6 [95% CI, -16.6 to 3.4]; P = .20). There were no significant differences in ICU-acquired infections, duration of mechanical ventilation, or lengths of ICU or hospital stays. CONCLUSIONS AND RELEVANCE: Among immunocompromised patients admitted to the ICU with hypoxemic acute respiratory ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/7100705Test; http://hdl.handle.net/1854/LU-7100705Test; http://dx.doi.org/10.1001/jama.2015.12402Test; https://biblio.ugent.be/publication/7100705/file/7104655Test |
| DOI: | 10.1001/jama.2015.12402 |
| الإتاحة: | https://doi.org/10.1001/jama.2015.12402Test https://biblio.ugent.be/publication/7100705Test http://hdl.handle.net/1854/LU-7100705Test https://biblio.ugent.be/publication/7100705/file/7104655Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.2BB85F01 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jama.2015.12402 |
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