دورية أكاديمية
MSC microvesicles loaded G-quadruplex-enhanced circular single-stranded DNA-9 inhibits tumor growth by targeting MDSCs ...
| العنوان: | MSC microvesicles loaded G-quadruplex-enhanced circular single-stranded DNA-9 inhibits tumor growth by targeting MDSCs ... |
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| المؤلفون: | Han, Jingxia, Qin, Rong, Zheng, Shaoting, Hou, Xiaohui, Wang, Xiaorui, An, Huihui, Li, Zhongwei, Li, Yinan, Zhang, Heng, Zhai, Denghui, Liu, Huijuan, Meng, Jing, Sun, Tao |
| بيانات النشر: | figshare |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Space Science, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Chemical Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Cancer, Plant Biology, FOS Biological sciences |
| الوصف: | Background Myeloid-derived suppressor cells (MDSCs) promote tumor growth, metastasis, and lead to immunotherapy resistance. Studies revealed that miRNAs are also expressed in MDSCs and promote the immunosuppressive function of MDSCs. Currently, few studies have been reported on inducible cellular microvesicle delivery of nucleic acid drugs targeting miRNA in MDSCs for the treatment of malignant tumors. Results and conclusion In this study, we designed an artificial DNA named G-quadruplex-enhanced circular single-stranded DNA-9 (G4-CSSD9), that specifically adsorbs the miR-9 sequence. Its advanced DNA folding structure, rich in tandem repeat guanine (G-quadruplex), also provides good stability. Mesenchymal stem cells (MSCs) were prepared into nanostructured vesicles by membrane extrusion. The MSC microvesicles-encapsulated G4-CSSD9 (MVs@G4-CSSD9) was delivered into MDSCs, which affected the downstream transcription and translation process, and reduced the immunosuppressive function of MDSCs, so as to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.6084/m9.figshare.c.7230302 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.c.7230302Test https://springernature.figshare.com/collections/MSC_microvesicles_loaded_G-quadruplex-enhanced_circular_single-stranded_DNA-9_inhibits_tumor_growth_by_targeting_MDSCs/7230302Test |
| حقوق: | Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 |
| رقم الانضمام: | edsbas.2B88BFA9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.c.7230302 |
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