دورية أكاديمية
Genomic epidemiology of the clinically dominant clonal complex 1 in the Listeria monocytogenes population in the UK
| العنوان: | Genomic epidemiology of the clinically dominant clonal complex 1 in the Listeria monocytogenes population in the UK |
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| المؤلفون: | Fotopoulou, Emily T., Jenkins, Claire, Barker, Clare R., Painset, Anais, Didelot, Xavier, Simbo, Ameze, Douglas, Amy, Godbole, Gauri, Jorgensen, Frieda, Gharbia, Saheer, McLauchlin, Jim |
| بيانات النشر: | Microbiology Society |
| سنة النشر: | 2024 |
| المجموعة: | The University of Warwick: WRAP - Warwick Research Archive Portal |
| مصطلحات موضوعية: | QH Natural history, QR Microbiology, RA Public aspects of medicine, RB Pathology |
| الوصف: | Listeria monocytogenes is a food-borne pathogen, typically affecting the elderly, immunocompromised patients and pregnant women. The aim of this study was to determine the population structure of L. monocytogenes clonal complex 1 (CC1) in the UK and describe the genomic epidemiology of this clinically significant CC. We interrogated a working dataset of 4073 sequences of L. monocytogenes isolated between January 2015 and December 2020 from human clinical specimens, food and/or food-production environments. A minimum spanning tree was reconstructed to determine the population structure of L. monocytogenes in the UK. Subsequent analysis focused on L. monocytogenes CC1, as the cause of the highest proportion of invasive listeriosis in humans. Sequencing data was integrated with metadata on food and environmental isolates, and information from patient questionnaires, including age, sex and clinical outcomes. All isolates either belonged to lineage I (n=1299/4073, 32%) or lineage II (n=2774/4073, 68%), with clinical isolates from human cases more likely to belong to lineage I (n=546/928, 59%) and food isolates more likely to belong to lineage II (n=2352/3067, 77%). Of the four largest CCs, CC1 (n=237) had the highest proportion of isolates from human cases of disease (CC1 n=160/237, 67.5 %; CC121 n=13/843, 2 %; CC9 n=53/360, 15 %; CC2 n=69/339, 20%). Within CC1, most cases were female (n=95/160, 59%, P=0.01771) and the highest proportion of cases were in people >60 years old (39/95, 41%, P=1.314×10−6) with a high number of them aged 20–39 years old (n=35/95, 37%) most linked to pregnancy-related listeriosis (n=29/35, 83%). Most of the male cases were in men aged over 60 years old (40/65, 62%), and most of the fatal cases in both males and females were identified in this age group (42/55, 76%). Phylogenetic analysis revealed 23 5 SNP single linkage clusters comprising 80/237 (34 %) isolates with cluster sizes ranging from 2 to 19. Five 5 SNP clusters comprised isolates from human cases and an implicated food item. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://wrap.warwick.ac.uk/182397/1/mgen001155.pdfTest; Fotopoulou, Emily T., Jenkins, Claire, Barker, Clare R., Painset, Anais, Didelot, Xavier, Simbo, Ameze, Douglas, Amy, Godbole, Gauri, Jorgensen, Frieda, Gharbia, Saheer and McLauchlin, Jim (2024) Genomic epidemiology of the clinically dominant clonal complex 1 in the Listeria monocytogenes population in the UK. Microbial Genomics, 10 (1). doi:10.1099/mgen.0.001155 ISSN 2057-5858. (In Press) |
| DOI: | 10.1099/mgen.0.001155 |
| الإتاحة: | https://doi.org/10.1099/mgen.0.001155Test https://wrap.warwick.ac.uk/182397Test/ https://wrap.warwick.ac.uk/182397/1/mgen001155.pdfTest |
| رقم الانضمام: | edsbas.2B6D5ADD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1099/mgen.0.001155 |
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