دورية أكاديمية
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
| العنوان: | Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors |
|---|---|
| المؤلفون: | Rodrigues-Diez, Raquel, Ballesteros-Martínez, Constanza, Moreno-Carriles, Rosa María, Nistal Herrera, Juan Francisco, Díaz del Campo, Lucía S., Cachofeiro, Victoria, Dalli, Jesmond, García-Redondo, Ana B., Redondo, Juan M., Salaices, Mercedes, Briones, Ana M. |
| المساهمون: | Universidad de Cantabria |
| المصدر: | Biomedicine & Pharmacotherapy, 2024, 174, 116564 |
| بيانات النشر: | Editions Scientifiques Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Universidad de Cantabria: UCrea |
| مصطلحات موضوعية: | Resolvin D2, Vascular remodeling, Endothelial dysfunction, Hypertension, Obesity, Resolution of inflammation |
| الوصف: | During resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involved in SPMs synthesis (ALOXs), SPMs receptors and pro-inflammatory genes. In an experimental model of aortic dilation induced by high fat diet (HFD, 60%, eighteen weeks) and angiotensin II (AngII) infusion (four weeks), we studied the effect of RvD2 administration in aorta and small mesenteric arteries structure and function and markers of inflammation. In human macrophages we evaluated the effects of AngII and RvD2 in macrophages function and SPMs profile. In patients, we found positive correlations between AAA and obesity, and between AAA and expression of ALOX15, RvD2 receptor GPR18, and pro-inflammatory genes. There was an inverse correlation between the expression of aortic ALOX15 and AAA growth rate. In the mice model, RvD2 partially prevented the HFD plus AngII-induced obesity and adipose tissue inflammation, hypertension, aortic and mesenteric arteries remodeling, hypercontratility and endothelial dysfunction, and the expression of vascular proinflammatory markers and cell apoptosis. In human macrophages, RvD2 prevented AngII-induced impaired efferocytosis and switched SPMs profile. RvD2 might represent a novel protective strategy in preventing vascular damage associated to hypertension and obesity likely through effects in vascular and immune cells. ; Funding: This work is supported by SAF2016-80305P, funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”, PID2020-116498RB-I00 to AMB and PID2021-122388OB-100 to JMR funded by MCIN/AEI/10.13039/501100011033, Comunidad de ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0753-3322 1950-6007 |
| العلاقة: | https://doi.org/10.1016/j.biopha.2024.116564Test; SAF2016-80305P; https://hdl.handle.net/10902/32998Test |
| DOI: | 10.1016/j.biopha.2024.116564 |
| الإتاحة: | https://doi.org/10.1016/j.biopha.2024.116564Test https://hdl.handle.net/10902/32998Test |
| حقوق: | © 2024 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license. ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.2B5D6ECE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 07533322 19506007 |
|---|---|
| DOI: | 10.1016/j.biopha.2024.116564 |