دورية أكاديمية
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC)
| العنوان: | Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC) |
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| المؤلفون: | Albinger-Hegyi, A, Stoeckli, S J, Schmid, S, Storz, M, Iotzova, G, Probst-Hensch, N M, Rehrauer, H, Tinguely, M, Moch, H, Hegyi, I |
| المصدر: | Albinger-Hegyi, A; Stoeckli, S J; Schmid, S; Storz, M; Iotzova, G; Probst-Hensch, N M; Rehrauer, H; Tinguely, M; Moch, H; Hegyi, I (2010). Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC). International Journal of Cancer, 126(11):2653 -2662. |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2010 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Functional Genomics Center Zurich, Clinic for Otorhinolaryngology, Dermatology Clinic, Institute of Pathology and Molecular Pathology, Systems Biology / Functional Genomics, 570 Life sciences, biology, 610 Medicine & health |
| الوصف: | Proteins of the lysyl oxidase (LOX) family are important modulators of the extracellular matrix. However, they have an important role in the tumour development as well as in tumour progression. To evaluate the diagnostic and prognostic value of the LOX protein in oral and oropharyngeal squamous cell carcinoma (OSCC) we performed QRT-PCR and immunohistochemical analysis on two tissue microarrays (622 tissue samples in total). Significantly higher LOX expression was detected in high grade dysplastic oral mucosa as well as in OSCC when compared to normal oral mucosa (P < 0.001). High LOX expression was correlated with clinical TNM stage (P = 0.020), lymph node metastases for the entire cohort (P < 0.001), as well as in the subgroup of small primary tumours (T1/T2, P < 0.001). Moreover, high LOX expression was correlated with poor overall survival (P = 0.004) and disease specific survival (P = 0.037). In a multivariate analysis, high LOX expression was an independent prognostic factor, predicting unfavourable overall survival.In summary, LOX expression is an independent prognostic biomarker and a predictor of lymph node metastasis in OSCC. Moreover, LOX overexpression may be an early phenomenon in the pathogenesis of OSCC and thus an attractive novel target for chemopreventive and therapeutic strategies. (c) 2009 UICC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0020-7136 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/25946/10/Albinger_IJC_2010.pdfTest; info:pmid/19816945; urn:issn:0020-7136 |
| DOI: | 10.5167/uzh-25946 |
| DOI: | 10.1002/ijc.24948 |
| الإتاحة: | https://doi.org/10.5167/uzh-2594610.1002/ijc.24948Test https://www.zora.uzh.ch/id/eprint/25946Test/ https://www.zora.uzh.ch/id/eprint/25946/10/Albinger_IJC_2010.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2B43D654 |
| قاعدة البيانات: | BASE |
| تدمد: | 00207136 |
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| DOI: | 10.5167/uzh-25946 |