التفاصيل البيبلوغرافية
| العنوان: |
Renal Effects of A Nonhypotensive IV Dose of Felodipine |
| المؤلفون: |
Larochelle, P., Cusson, J. R., du Souich, P., Thibault, G., Edgar, B. |
| المصدر: |
The Journal of Clinical Pharmacology ; volume 33, issue 8, page 732-737 ; ISSN 0091-2700 1552-4604 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
1993 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
To evaluate the natriuretic effect of a nonhypotensive dose of felodipine, 11 healthy volunteers (age: 21–28 years) on a high‐sodium diet received the drug or its vehicle in a double‐blind, randomized, crossover study. Administered intravenously at a dose level of 7.5 μg/min for 30 minutes followed by 5 μg/min for 120 minutes, felodipine increased natriuresis (546 ± 69 vs. 454 ± 39 μmol/min, P <0.001) and diuresis (8.9 ± 0.6 vs. 7.5 ± 0.5 mL/min), compared to its vehicle. Renal plasma flow tended to be augmented, but there was a significant reduction of renal vascular resistance (0.085 ± 0.004 vs. 0.101 ± 0.012 mm Hg/mL/min, P <0.03). The glomerular filtration rate was slightly decreased and proximal sodium reabsorption was diminished with no measurable effect on distal function. Felodipine stimulated plasma renin activity, but produced no changes in plasma atrial natriuretic factor, cGMP, aldosterone, and atrial vasopressin levels. In conclusion, felodipine induced natriuresis and diuresis while reducing proximal tubular sodium reabsorption. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/j.1552-4604.1993.tb05615.x |
| الإتاحة: |
https://doi.org/10.1002/j.1552-4604.1993.tb05615.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.2B3C7911 |
| قاعدة البيانات: |
BASE |
