دورية أكاديمية
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP:report from an International DLBCL Rituximab-CHOP Consortium Program Study
| العنوان: | Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP:report from an International DLBCL Rituximab-CHOP Consortium Program Study |
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| المؤلفون: | Xu-Monette, Zijun Y, Wu, Lin, Visco, Carlo, Tai, Yu Chuan, Tzankov, Alexander, Liu, Wei-min, Montes-Moreno, Santiago, Dybkaer, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L, Hsi, Eric D, Zhao, X Frank, Choi, William W L, Zhao, Xiaoying, van Krieken, J Han, Huang, Qin, Huh, Jooryung, Ai, Weiyun, Ponzoni, Maurilio, Ferreri, Andrés J M, Zhou, Fan, Kahl, Brad S, Winter, Jane N, Xu, Wei, Li, Jianyong, Go, Ronald S, Li, Yong, Piris, Miguel A, Møller, Michael B, Miranda, Roberto N, Abruzzo, Lynne V, Medeiros, L Jeffrey, Young, Ken H |
| المصدر: | Xu-Monette , Z Y , Wu , L , Visco , C , Tai , Y C , Tzankov , A , Liu , W , Montes-Moreno , S , Dybkaer , K , Chiu , A , Orazi , A , Zu , Y , Bhagat , G , Richards , K L , Hsi , E D , Zhao , X F , Choi , W W L , Zhao , X , van Krieken , J H , Huang , Q , Huh , J , Ai , W , Ponzoni , M , Ferreri , .... |
| سنة النشر: | 2012 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Adult, Aged, Alleles, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols, Cohort Studies, Computational Biology, Cyclophosphamide, Doxorubicin, Exons, Female, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Loss of Heterozygosity, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Mutation, Mutation Rate, Missense, Neoplasm Staging, Prednisone, Prognosis |
| الوصف: | TP53 mutation is an independent marker of poor prognosis in patients with diffuse large B-cell lymphoma (DLBCL) treated with cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (CHOP) therapy. However, its prognostic value in the rituximab immunochemotherapy era remains undefined. In the present study of a large cohort of DLBCL patients treated with rituximab plus CHOP (R-CHOP), we show that those with TP53 mutations had worse overall and progression-free survival compared with those without. Unlike earlier studies of patients treated with CHOP, TP53 mutation has predictive value for R-CHOP-treated patients with either the germinal center B-cell or activated B-cell DLBCL subtypes. Furthermore, we identified the loop-sheet-helix and L3 motifs in the DNA-binding domain to be the most critical structures for maintaining p53 function. In contrast, TP53 deletion and loss of heterozygosity did not confer worse survival. If gene mutation data are not available, immunohistochemical analysis showing > 50% cells expressing p53 protein is a useful surrogate and was able to stratify patients with significantly different prognoses. We conclude that assessment of TP53 mutation status is important for stratifying R-CHOP-treated patients into distinct prognostic subsets and has significant value in the design of future therapeutic strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/807269b3-701b-45aa-babe-6b42373469f0Test |
| DOI: | 10.1182/blood-2012-05-433334 |
| الإتاحة: | https://doi.org/10.1182/blood-2012-05-433334Test https://portal.findresearcher.sdu.dk/da/publications/807269b3-701b-45aa-babe-6b42373469f0Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.2B3984F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2012-05-433334 |
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