التفاصيل البيبلوغرافية
| العنوان: |
AB1325 DIAGNOSTIC DELAY IN FAMILIAL MEDITERRANEAN FEVER: IS IT STILL A PROBLEM? |
| المؤلفون: |
Yuzbasioglu, M. B., Ayla, A. Y., Besiroglu, I., Baspinar, S. N., Yenigun, S., Durucan, I., Alkan, A., Gazioglu, M. E., Hiyamli, M. F., Sarac, I., Ozdogan, H., Ugurlu, S. |
| المصدر: |
Annals of the Rheumatic Diseases ; volume 81, issue Suppl 1, page 1768.2-1769 ; ISSN 0003-4967 1468-2060 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
General Biochemistry, Genetics and Molecular Biology, Immunology, Immunology and Allergy, Rheumatology |
| الوصف: |
Background Familial Mediterranean fever (FMF) is a rare hereditary autoinflammatory disease with disease onset in childhood in most cases. Although autoinflammatory disease awareness is increasing among physicians, delayed diagnosis is still prevalent as a cause of greater morbidity[1]. Objectives We aimed to study the characteristics of FMF patients diagnosed between 2000-2010 and 2011-2021 and to see if there was a difference in diagnostic delay. Methods We retrospectively evaluated the medical records of the FMF patients followed up in our rheumatology clinic that were diagnosed between 2000-2021 and split them into two groups according to the year they received their diagnosis. There were 1151 patients diagnosed between 2000-2010 (Group 1) and 821 patients diagnosed between 2011-2021 (Group 2). The data studied included gender, age of onset, diagnostic delay, attack characteristics, MEFV mutation, and family history. Results The median current age of patients in Group 1 is 37 years (IQR:30-46) and the median current age of the patients in Group 2 is 36 years (IQR:29-44). The female to male ratio was 1.57 in Group 1 and 1.75 in Group 2, with no significant difference between the groups. Group 2 had later disease onset (p<0.001) and later diagnosis (p<0.001) than Group 1 as shown in the Table 1. The proportion of patients with at least one M694V mutation was higher in Group 2 (p<0.001). The attack durations did not vary between the groups. There was no significant difference in the prevalence of abdominal pain, fever, arthritis, and arthralgia between Group 1 and Group 2. Chest pain (p=0.005), myalgia (p<0.001), and erysipelas-like erythema (p=0.041) were more common in Group 2 than Group 1. Patients with positive family history were more frequent in Group 2 than Group 1 (p=0.046). Table 1. Group 1 (2000-2010, n=1151) Group 2 (2011-2021, n=821) p Female/Male, n 704/447 522/299 0.275 Age at onset, median (IQR) years 13 (7-21) 18 (12-26) <0.001 Delay in diagnosis, median (IQR) years 4 (1-11) ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/annrheumdis-2022-eular.5322 |
| الإتاحة: |
https://doi.org/10.1136/annrheumdis-2022-eular.5322Test |
| رقم الانضمام: |
edsbas.2AD64706 |
| قاعدة البيانات: |
BASE |
