دورية أكاديمية
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
| العنوان: | The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. |
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| المؤلفون: | Heredia, Fabiana, Volonté, Yanel, Cardoso, Gisele A, Macedo, André, Kotowicz, Malwina, Prado Spalm, Facundo H, Dibo, Marcos J, Monfardini, Raquel D, Torres, Tatiana T, Mendes, César S, Garelli, Andres, Gontijo, Alisson M, Pereirinha, Joana, Fernandez-Acosta, Magdalena, Casimiro, Andreia P, Belém, Cláudia G, Viegas, Filipe, Tanaka, Kohtaro, Menezes, Juliane, Arana, Maite |
| المصدر: | Nature Communications 12(1), 3328 (2021). doi:10.1038/s41467-021-23218-5 |
| بيانات النشر: | Nature Publishing Group UK |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/500, Animals, Drosophila: metabolism, Drosophila Proteins: genetics, Drosophila Proteins: metabolism, Drosophila melanogaster: genetics, Drosophila melanogaster: metabolism, Ecdysone: genetics, Ecdysone: pharmacology, Epidermal Cells: metabolism, Epidermis: metabolism, Intercellular Signaling Peptides and Proteins, Larva: metabolism, Metamorphosis, Biological, Morphogenesis: drug effects, Morphogenesis: genetics, Neurons: metabolism, Receptors, G-Protein-Coupled: genetics, G-Protein-Coupled: metabolism, Relaxin: metabolism, Drosophila Proteins, Lgr3 protein, Drosophila, G-Protein-Coupled, insulin-like peptide 8, Ecdysone, Relaxin |
| جغرافية الموضوع: | DE |
| الوصف: | Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:34099654; info:eu-repo/semantics/altIdentifier/issn/2041-1723; https://pub.dzne.de/record/164161Test; https://pub.dzne.de/search?p=id:%22DZNE-2022-00817%22Test |
| الإتاحة: | https://doi.org/10.1038/s41467-021-23218-5Test https://pub.dzne.de/record/164161Test https://pub.dzne.de/search?p=id:%22DZNE-2022-00817%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2A7D96A2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |