دورية أكاديمية
Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction
| العنوان: | Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction |
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| المؤلفون: | Sawaki, Daigo, Zhang, Yanyan, Mohamadi, Amel, Pini, Maria, Mezdari, Zaineb, Lipskaia, Larissa, Naushad, Suzain, Lamendour, Lucille, Altintas, Dogus Murat, Breau, Marielle, Liang, Hao, Halfaoui, Maissa, Delmont, Thaïs, Surenaud, Mathieu, Rousseau, Déborah, Yoshimitsu, Takehiko, Louache, Fawzia, Adnot, Serge, Henegar, Corneliu, Gual, Philippe, Czibik, Gabor, Derumeaux, Geneviève |
| المساهمون: | IMRB - SMCD/"Senescence, Metabolism and Cardiovascular Diseases" Créteil (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - PGD/"Pathophysiology of Glomerular Diseases" Créteil (U955 Inserm - UPEC), IMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" Créteil (U955 Inserm - UPEC), IMRB - "Transfusion et Maladies du Globule Rouge" Créteil (U955 Inserm - UPEC), Département de physiologie (CHU Henri Mondor), Hôpital Henri Mondor, RHU CARMMA grant and Fondation pour la Recherche Médicale (EQU202003010186) |
| المصدر: | ISSN: 2379-3708 ; JCI Insight ; https://hal.science/hal-04199061Test ; JCI Insight, 2023, 8 (8), ⟨10.1172/jci.insight.145811⟩. |
| بيانات النشر: | HAL CCSD American Society for Clinical Investigation |
| سنة النشر: | 2023 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Osteopontin, Senescence, Macrophage, Adipose tissue, Aging, MESH: Adipose tissue, Animals, Macrophages, Mice, Obesity/genetics, Osteopontin/genetics, phagocytosis, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Adipose tissue macrophages (ATMs) play an important role in obesity and inflammation, and they accumulate in adipose tissue (AT) with aging. Furthermore, increased ATM senescence has been shown in obesity-related AT remodeling and dysfunction. However, ATM senescence and its role are unclear in age-related AT dysfunction. Here, we show that ATMs (a) acquire a senescence-like phenotype during chronological aging; (b) display a global decline of basic macrophage functions such as efferocytosis, an essential process to preserve AT homeostasis by clearing dysfunctional or apoptotic cells; and (c) promote AT remodeling and dysfunction. Importantly, we uncover a major role for the age-associated accumulation of osteopontin (OPN) in these processes in visceral AT. Consistently, loss or pharmacologic inhibition of OPN and bone marrow transplantation of OPN-/- mice attenuate the ATM senescence-like phenotype, preserve efferocytosis, and finally restore healthy AT homeostasis in the context of aging. Collectively, our findings implicate pharmacologic OPN inhibition as a viable treatment modality to counter ATM senescence-mediated AT remodeling and dysfunction during aging. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04199061; https://hal.science/hal-04199061Test; https://hal.science/hal-04199061/documentTest; https://hal.science/hal-04199061/file/Osteopontin%20promotes%20age%20related%20adipose%20tissue%20remodeling%20through%20senescenceassociated%20macrophage%20dysfunction%20%281%29.pdfTest |
| DOI: | 10.1172/jci.insight.145811 |
| الإتاحة: | https://doi.org/10.1172/jci.insight.145811Test https://hal.science/hal-04199061Test https://hal.science/hal-04199061/documentTest https://hal.science/hal-04199061/file/Osteopontin%20promotes%20age%20related%20adipose%20tissue%20remodeling%20through%20senescenceassociated%20macrophage%20dysfunction%20%281%29.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2A5473B3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/jci.insight.145811 |
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