دورية أكاديمية
Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice
| العنوان: | Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice |
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| المؤلفون: | van Beek, Dirk Jan, Wessels, Frank J., Pieterman, Carolina R.C., van de Ven, Annenienke C., de Herder, Wouter W., Dekkers, Olaf M., Zandee, Wouter T., Drent, Madeleine L., Bisschop, Peter H., Havekes, Bas, Borel Rinkes, Inne H.M., Vriens, Menno R., Valk, Gerlof D. |
| المصدر: | van Beek , D J , Wessels , F J , Pieterman , C R C , van de Ven , A C , de Herder , W W , Dekkers , O M , Zandee , W T , Drent , M L , Bisschop , P H , Havekes , B , Borel Rinkes , I H M , Vriens , M R & Valk , G D 2022 , ' Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice ' , Frontiers in Endocrinology , vol. 13 , 926491 . .... |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Background: In multiple endocrine neoplasia type 1 (MEN1), pancreatic neuroendocrine tumors (PanNETs) have a high prevalence and represent the main cause of death. This study aimed to assess the diagnostic accuracy of the currently used conventional pancreatic imaging techniques and the added value of fine needle aspirations (FNAs). Methods: Patients who had at least one imaging study were included from the population-based MEN1 database of the DutchMEN Study Group from 1990 to 2017. Magnetic resonance imaging (MRI), computed tomography (CT), endoscopic ultrasonography (EUS), FNA, and surgical resection specimens were obtained. The first MRI, CT, or EUS was considered as the index test. For a comparison of the diagnostic accuracy of MRI versus CT, patients with their index test taken between 2010 and 2017 were included. The reference standard consisted of surgical histopathology or radiological follow-up. Results: A total of 413 patients (92.8% of the database) underwent 3,477 imaging studies. The number of imaging studies per patient increased, and a preference for MRI was observed in the last decade. Overall diagnostic accuracy was good with a positive (PPV) and negative predictive value (NPV) of 88.9% (95% confidence interval, 76.0–95.6) and 92.8% (89.4–95.1), respectively, for PanNET in the pancreatic head and 92.0% (85.3–96.0) and 85.3% (80.5–89.1), respectively, in the body/tail. For MRI, PPV and NPV for pancreatic head tumors were 100% (76.1–100) and 87.1% (76.3–93.6) and for CT, 60.0% (22.9–88.4) and 70.4% (51.3–84.3), respectively. For body/tail tumors, PPV and NPV were 91.3% (72.0–98.8) and 87.0% (75.3–93.9), respectively, for MRI and 100% (74.9–100) and 77.8% (54.3–91.5), respectively, for CT. Pathology confirmed a PanNET in 106 out of 110 (96.4%) resection specimens. FNA was performed on 34 lesions in 33 patients and was considered PanNET in 24 [all confirmed PanNET by histology (10) or follow-up (14)], normal/cyst/unrepresentative in 6 (all confirmed PanNET by follow-up), and adenocarcinoma in 4 (2 ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/d308556f-8f74-430b-917a-795bc9a9d001Test |
| DOI: | 10.3389/fendo.2022.926491 |
| الإتاحة: | https://doi.org/10.3389/fendo.2022.926491Test https://pure.eur.nl/en/publications/d308556f-8f74-430b-917a-795bc9a9d001Test https://pure.eur.nl/ws/files/70004547/Diagnosing_pancreatic_neuroendocrine_tumors_in_patients_with_multiple_endocrine_neoplasia_type_1_in_daily_practice.pdfTest http://www.scopus.com/inward/record.url?scp=85140310846&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2A516DBD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2022.926491 |
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