دورية أكاديمية
Liposomes can both enhance or reduce drugs penetration through the skin
| العنوان: | Liposomes can both enhance or reduce drugs penetration through the skin |
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| المؤلفون: | Peralta, Ma. F., Guzmán, Ma. L., Pérez, A. P., Apezteguia, G. A., Fórmica, Ma. L., Romero, E. L., Olivera, Ma. E., Carrer, D. C. |
| المصدر: | Scientific Reports ; volume 8, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | The adequate formulation of topical vehicles to treat skin diseases is particularly complex. A desirable formulation should enhance the accumulation of the active drugs in the target tissue (the skin), while avoiding the penetration enhancement to be so large that the drugs reach the systemic circulation in toxic amounts. We have evaluated the transcutaneous penetration of three drugs chosen for their widely variable physicochemical properties: Amphotericin B, Imiquimod and Indole. We incorporated the drugs in fluid or ultra-flexible liposomes. Ultra-flexible liposomes produced enhancement of drug penetration into/through human skin in all cases in comparison with fluid liposomes without detergent, regardless of drug molecular weight. At the same time, our results indicate that liposomes can impede the transcutaneous penetration of molecules, in particular small ones. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-018-31693-y |
| الإتاحة: | https://doi.org/10.1038/s41598-018-31693-yTest https://www.nature.com/articles/s41598-018-31693-y.pdfTest https://www.nature.com/articles/s41598-018-31693-yTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.2A4BC95B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-018-31693-y |
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