دورية أكاديمية
Changing Faces of Obstructive Sleep Apnea: Treatment Effects by Cluster Designation in the Icelandic Sleep Apnea Cohort
| العنوان: | Changing Faces of Obstructive Sleep Apnea: Treatment Effects by Cluster Designation in the Icelandic Sleep Apnea Cohort |
|---|---|
| المؤلفون: | Pien, Grace W, Ye, Lichuan, Keenan, Brendan T, Maislin, Greg, Björnsdóttir, Erla, Arnardottir, Erna Sif, Benediktsdottir, Bryndis, Gislason, Thorarinn, Pack, Allan I |
| المساهمون: | 1 Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA Show more 2 Northeastern Univ, Sch Nursing, Bouve Coll Hlth Sci, Boston, MA 02115 USA Show more 3 Univ Penn, Perelman Sch Med, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA 4 Landspitali, Dept Sleep, Reykjavik, Iceland Show more 5 Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland Show more 6 Univ Penn, Dept Med, Div Sleep Med, Perelman Sch Med, Philadelphia, PA 19104 USA |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2018 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Kæfisvefn, PAD12, NAF12, Sleep Apnea, Obstructive |
| الوصف: | To access publisher's full text version of this article click on the hyperlink below ; STUDY OBJECTIVES: Distinct clinical phenotypes of obstructive sleep apnea (OSA) have been identified: Disturbed Sleep, Minimally Symptomatic, and Sleepy. Determining whether these phenotypes respond differently to standard treatment helps us to create a foundation for personalized therapies. We compared responses to positive airway pressure (PAP) therapy in these clinical OSA phenotypes. METHODS: The study sample included 706 patients from the Icelandic Sleep Apnea Cohort with moderate-to-severe OSA who were prescribed PAP. Linear and logistic mixed models were used to compare 2-year changes in demographics, comorbid diseases, and sleep-related health issues within and across OSA clinical phenotypes. Relationships between changes in symptoms and PAP adherence were also examined. RESULTS: Overall, effect sizes were moderate to large when comparing sleepiness, insomnia-related, and apneic symptom changes in the Sleepy group with changes in other two groups, especially those in the Minimally Symptomatic group. Within the Disturbed Sleep group, PAP users and nonusers demonstrated similar changes in insomnia-related symptoms. The Minimally Symptomatic group remained relatively asymptomatic, but reported significant decreases in daytime sleepiness and physical fatigue; PAP users generally had larger improvements. The Sleepy group had reductions in nearly all measured symptoms, including large reductions in drowsy driving; almost all of these improvements were greater among PAP users than nonusers. CONCLUSIONS: OSA treatment response patterns differed by initial clinical phenotype and PAP adherence. Individuals with insomnia-related symptoms may require additional targeted therapy for these complaints. These findings underscore the need for a personalized approach to management that recognizes patients with a range of OSA presentations. ; National Institutes of Health |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0161-8105 1550-9109 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pmc/journals/369Test/; Changing Faces of Obstructive Sleep Apnea: Treatment Effects by Cluster Designation in the Icelandic Sleep Apnea Cohort 2018 Sleep; http://hdl.handle.net/2336/620555Test; Sleep |
| DOI: | 10.1093/sleep/zsx201 |
| الإتاحة: | https://doi.org/10.1093/sleep/zsx201Test http://hdl.handle.net/2336/620555Test |
| حقوق: | Archived with thanks to Sleep ; National Consortium - Landsaðgangur |
| رقم الانضمام: | edsbas.2A397B7F |
| قاعدة البيانات: | BASE |
| تدمد: | 01618105 15509109 |
|---|---|
| DOI: | 10.1093/sleep/zsx201 |