دورية أكاديمية
Superficial Characteristics and Functionalization Effectiveness of Non-Toxic Glutathione-Capped Magnetic, Fluorescent, Metallic and Hybrid Nanoparticles for Biomedical Applications
| العنوان: | Superficial Characteristics and Functionalization Effectiveness of Non-Toxic Glutathione-Capped Magnetic, Fluorescent, Metallic and Hybrid Nanoparticles for Biomedical Applications |
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| المؤلفون: | Fernandez-Ponce, C., Manuel, J. M., Fernandez-Cisnal, R., Felix, E., Beato-Lopez, J., Munoz-Miranda, J. P., Beltran, A. M., Santos, A. J., Morales, F. M., Yeste, M. P., Bomati-Miguel, O., Litran, R., Garcia-Cozar, F. |
| المساهمون: | Fernandez-Ponce, C. Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz 11003, Spain, Fernandez-Cisnal, R. Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz 11003, Spain, Munoz-Miranda, J. P. Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz 11003, Spain, Garcia-Cozar, F. Univ Cadiz, Dept Biomed Biotechnol & Publ Hlth, Cadiz 11003, Spain, Fernandez-Ponce, C. Inst Biomed Res Cadiz INIBICA, Cadiz 11003, Spain, Fernandez-Cisnal, R. Inst Biomed Res Cadiz INIBICA, Cadiz 11003, Spain, Munoz-Miranda, J. P. Inst Biomed Res Cadiz INIBICA, Cadiz 11003, Spain, Garcia-Cozar, F. Inst Biomed Res Cadiz INIBICA, Cadiz 11003, Spain, Manuel, J. M. Univ Cadiz, Dept Condensed Matter Phys, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Felix, E. Univ Cadiz, Dept Condensed Matter Phys, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Bomati-Miguel, O. Univ Cadiz, Dept Condensed Matter Phys, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Litran, R. Univ Cadiz, Dept Condensed Matter Phys, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Beato-Lopez, J. Univ Publ tgNavarra, Dept Ciencias, Inst Adv Mat INAMAT, Campus Arrosadia, Pamplona 31006, Spain, Beltran, A. M. Dept Ingn & Ciencia Mat & Transporte, Seville 41011, Spain, Santos, A. J. Univ Cadiz, Dept Mat Sci & Met Engn & Inorgan Chem, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Morales, F. M. Univ Cadiz, Dept Mat Sci & Met Engn & Inorgan Chem, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Yeste, M. P. Univ Cadiz, Dept Mat Sci & Met Engn & Inorgan Chem, Fac Sci, IMEYMAT Inst Res Electron Microscopy & Mat, Cadiz 11510, Spain, Iniciativa Territorial Integrada, Junta de Andalucia, Ministry of Education and Science, Instituto Salud Carlos III, Spanish Ministry of Economy and Competitiveness Program "Plan I+D+i", subprogram "Retos" |
| بيانات النشر: | Mdpi |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | functionalization, glutathione, surface modifications, colloidal stability, cytotoxicity, electron microscopy, magnetic nanoparticle, gold nanoparticle, quantum dot |
| الوصف: | An optimal design of nanoparticles suitable for biomedical applications requires proper functionalization, a key step in the synthesis of such nanoparticles, not only for subsequent crosslinking to biological targets and to avoid cytotoxicity, but also to endow these materials with colloidal stability. In this sense, a reliable characterization of the effectiveness of the functionalization process would, therefore, be crucial for subsequent bioconjugations. In this work, we have analyzed glutathione as a means to functionalize four of the most widely used nanoparticles in biomedicine, one of which is a hybrid gold-magnetic-iron-oxide nanoparticle synthetized by a simple and novel method that we propose in this article. We have analyzed the colloidal characteristics that the glutathione capping provides to the different nanoparticles and, using information on the Z-potential, we have deduced the chemical group used by glutathione to link to the nanoparticle core. We have used electron microscopy for further structural and chemical characterization of the nanoparticles. Finally, we have evaluated nanoparticle cytotoxicity, studying cell viability after incubation with different concentrations of nanoparticles, showing their suitability for biomedical applications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2075-4701 |
| العلاقة: | http://hdl.handle.net/10668/19303Test; https://www.mdpi.com/2075-4701/11/3/383/pdf?version=1615546142Test; 633882800001 |
| DOI: | 10.3390/met11030383 |
| الإتاحة: | https://doi.org/10.3390/met11030383Test http://hdl.handle.net/10668/19303Test https://www.mdpi.com/2075-4701/11/3/383/pdf?version=1615546142Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.2A287E5B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20754701 |
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| DOI: | 10.3390/met11030383 |