دورية أكاديمية
Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study.
| العنوان: | Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study. |
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| المؤلفون: | Petry, Clive J, Ong, Ken K, Hughes, Ieuan A, Dunger, David B |
| بيانات النشر: | MDPI AG //dx.doi.org/10.3390/nu12113466 Nutrients |
| سنة النشر: | 2020 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | adiposity, development, fetal growth, gestational diabetes, minerals, vitamins, Adult, Birth Weight, Diabetes, Gestational, Dietary Supplements, Female, Glucose Tolerance Test, Humans, Infant, Newborn, Linear Models, Male, Micronutrients, Pregnancy, Prospective Studies, Skinfold Thickness, United Kingdom |
| الوصف: | Multiple micronutrient supplementation (MMS) in pregnancy has previously been associated with positive effects on fetal growth, but its value in high-income countries remains controversial. In this study, we investigated effects of pregnancy MMS on offspring size at birth and adiposity, along with risks of various maternal outcomes of pregnancy, using the prospective Cambridge Baby Growth Study. Maternal MMS was reported in 528 out of 970 women who completed pregnancy questionnaires. Gestational diabetes (GDM) was assessed using results from 75 g oral glucose tolerance tests at week 28 of pregnancy. Offspring size at birth was assessed using standard anthropometric measurements and adiposity using skinfold calipers. MMS was associated with increased risk of developing GDM (risk ratio = 1.86 (1.13-3.08), p = 0.02), as well as increased offspring size at birth in terms of weight (p = 0.03), head circumference (p = 0.04), and flank, and subscapular and triceps skinfold thicknesses (p = 0.04, 0.03, and 0.003, respectively). There was no association with quadriceps skinfold thickness (p = 0.2), suggesting that the increased adiposity was partially regionalized. In women who underwent oral glucose tolerance testing, nearly all of these associations were attenuated by adjusting for GDM. These results suggest that the increased offspring size at birth, including (regionalized) adiposity associated with pregnancy, and MMS may be partially related to the development of GDM. ; This study received funding from the European Union Framework 5 (QLK4-1999-01422); the Medical Research Council (7500001180, G1001995, U106179472); Newlife Foundation for Disabled Children (07/20); the Mothercare Charitable Foundation (RG54608) and the World Cancer Research Fund International (2004/03). We also acknowledge support from National Institute for Health Research Cambridge Biomedical Research Centre. KKO receives support from the Medical Research Council (Unit Programme number: MC_UU_12015/2). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/312744Test |
| DOI: | 10.17863/CAM.59845 |
| الإتاحة: | https://doi.org/10.17863/CAM.59845Test https://www.repository.cam.ac.uk/handle/1810/312744Test |
| حقوق: | All rights reserved |
| رقم الانضمام: | edsbas.2A1E4FCA |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.59845 |
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