دورية أكاديمية
Advancing the Management of Skull Base Chondrosarcomas: A Systematic Review of Targeted Therapies
| العنوان: | Advancing the Management of Skull Base Chondrosarcomas: A Systematic Review of Targeted Therapies |
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| المؤلفون: | Agosti, Edoardo, Zeppieri, Marco, Antonietti, Sara, Ius, Tamara, Fontanella, Marco Maria, Panciani, Pier Paolo |
| المساهمون: | Agosti, Edoardo, Zeppieri, Marco, Antonietti, Sara, Ius, Tamara, Fontanella, Marco Maria, Panciani, Pier Paolo |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| مصطلحات موضوعية: | chondrosarcoma, molecular pattern, outcome, systematic review, target therapies |
| الوصف: | Background: Chondrosarcomas rank as the second most common primary bone malignancy. Characterized by the production of a cartilaginous matrix, these tumors typically exhibit resistance to both radiotherapy (RT) and chemotherapy (CT), resulting in overall poor outcomes: a high rate of mortality, especially among children and adolescents. Due to the considerable resistance to current conventional therapies such as surgery, CT, and RT, there is an urgent need to identify factors contributing to resistance and discover new strategies for optimal treatment. Over the past decade, researchers have delved into the dysregulation of genes associated with tumor development and therapy resistance to identify potential therapeutic targets for overcoming resistance. Recent studies have suggested several promising biomarkers and therapeutic targets for chondrosarcoma, including isocitrate dehydrogenase (IDH1/2) and COL2A1. Molecule-targeting agents and immunotherapies have demonstrated favorable antitumor activity in clinical studies involving patients with advanced chondrosarcomas. In this systematic review, we delineate the clinical features of chondrosarcoma and provide a summary of gene dysregulation and mutation associated with tumor development, as well as targeted therapies as a promising molecular approach. Finally, we analyze the probable role of the tumor microenvironment in chondrosarcoma drug resistance. Methods: A systematic search was conducted across major medical databases (PubMed, Embase, and Cochrane Library) up to 10 November 2023. The search strategy utilized relevant Medical Subject Heading (MeSH) terms and keywords related to "chondrosarcomas", "target therapies", "immunotherapies", and "outcomes". The studies included in this review consist of randomized controlled trials, non-randomized controlled trials, and cohort studies reporting on the use of target therapies for the treatment of chondrosarcoma in human subjects. Results: Of the initial 279 articles identified, 40 articles were included in the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38541003; info:eu-repo/semantics/altIdentifier/wos/WOS:001192473000001; volume:14; issue:3; numberofpages:19; journal:JOURNAL OF PERSONALIZED MEDICINE; https://hdl.handle.net/11379/595765Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85188925849; https://www.mdpi.com/2075-4426/14/3/261Test |
| DOI: | 10.3390/jpm14030261 |
| الإتاحة: | https://doi.org/10.3390/jpm14030261Test https://hdl.handle.net/11379/595765Test https://www.mdpi.com/2075-4426/14/3/261Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.29BC465D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jpm14030261 |
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