دورية أكاديمية
Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner
| العنوان: | Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner |
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| المؤلفون: | Favre, Julie, Vessieres, Emilie, Guihot, Anne-Laure, Proux, Coralyne, Grimaud, Linda, Rivron, Jordan, Garcia, Manuela Cl, Réthoré, Léa, Zahreddine, Rana, Davezac, Morgane, Fébrissy, Chanaelle, Adlanmerini, Marine, Loufrani, Laurent, Procaccio, Vincent, Foidart, Jean-Marie, Flouriot, Gilles, Lenfant, Francoise, Fontaine, Coralie, Arnal, Jean-Françoise, Henrion, Daniel |
| المساهمون: | MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), FRM - DPC20171138957, Fondation pour la Recherche Médicale, Equipe FRM DEQ20160334924, Fondation pour la Recherche Médicale, ANR-18-CE14-0016-01, Agence Nationale de la Recherche, Fondation Lefoulon Delalande, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, 00086486, Fondation de France, Région Occitanie Pyrénées-Méditerranée, Institut Universitaire de France, ANR-18-CE14-0016,EstroShear,Rôle du récepteur aux œstrogènes alpha dans la mécanotransduction du flux: conséquences physiopathologiques(2018) |
| المصدر: | EISSN: 2050-084X ; eLife ; https://univ-angers.hal.science/hal-03483155Test ; eLife, 2021, 10, pp.e68695. ⟨10.7554/eLife.68695⟩ |
| بيانات النشر: | HAL CCSD eLife Sciences Publication |
| سنة النشر: | 2021 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | blood flow, cell biology, endothelium, estrogen receptors, mouse, resistance arteries, shear stress, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action whereas plasma membrane-located ERα accelerates endothelial healing. The genetic deficiency of ERα was associated with a reduction in flow-mediated dilation (FMD) in one man. Here, we evaluated ex vivo the role of ERα on FMD of resistance arteries. FMD, but not agonist (acetylcholine, insulin)-mediated dilation, was reduced in male and female mice lacking ERα ( Esr1 -/- mice) compared to wild-type mice and was not dependent on the presence of estrogens. In C451A-ERα mice lacking membrane ERα, not in mice lacking AF2-dependent nuclear ERα actions, FMD was reduced, and restored by antioxidant treatments. Compared to wild-type mice, isolated perfused kidneys of C451A-ERα mice revealed a decreased flow-mediated nitrate production and an increased H 2 O 2 production. Thus, endothelial membrane ERα promotes NO bioavailability through inhibition of oxidative stress and thereby participates in FMD in a ligand-independent manner. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34842136; hal-03483155; https://univ-angers.hal.science/hal-03483155Test; https://univ-angers.hal.science/hal-03483155/documentTest; https://univ-angers.hal.science/hal-03483155/file/Favre_elife-68695-v2.pdfTest; PUBMED: 34842136; PUBMEDCENTRAL: PMC8676342 |
| DOI: | 10.7554/eLife.68695 |
| الإتاحة: | https://doi.org/10.7554/eLife.68695Test https://univ-angers.hal.science/hal-03483155Test https://univ-angers.hal.science/hal-03483155/documentTest https://univ-angers.hal.science/hal-03483155/file/Favre_elife-68695-v2.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.298F45F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/eLife.68695 |
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