تقرير
Microglia regulate chandelier cell axo-axonic synaptogenesis
| العنوان: | Microglia regulate chandelier cell axo-axonic synaptogenesis |
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| المؤلفون: | Gallo, Nicholas B, Berisha, Artan, Van Aelst, Linda |
| سنة النشر: | 2022 |
| المجموعة: | Cold Spring Harbor Laboratory: CSHL Institutional Repository |
| مصطلحات موضوعية: | bioinformatics, GABA, genomics and proteomics, animal, axo-axonic synapse, cell types, cell types and functions, mammal, microglia, mouse, organs, tissues, organelles, rodent, small molecules, sub-cellular tissues: types and functions, synapse, synaptogenesis |
| الوصف: | SignificanceChandelier cells (ChCs) are a unique type of GABAergic interneuron that form axo-axonic synapses exclusively on the axon initial segment (AIS) of neocortical pyramidal neurons (PyNs), allowing them to exert powerful yet precise control over PyN firing and population output. The importance of proper ChC function is further underscored by the association of ChC connectivity defects with various neurological conditions. Despite this, the cellular mechanisms governing ChC axo-axonic synapse formation remain poorly understood. Here, we identify microglia as key regulators of ChC axonal morphogenesis and AIS synaptogenesis, and show that disease-induced aberrant microglial activation perturbs proper ChC synaptic development/connectivity in the neocortex. In doing so, such findings highlight the therapeutic potential of manipulating microglia to ensure proper brain wiring. |
| نوع الوثيقة: | report |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://repository.cshl.edu/id/eprint/40552/1/2022.Gallo.axo-axonic.pdfTest; Gallo, Nicholas B, Berisha, Artan, Van Aelst, Linda (March 2022) Microglia regulate chandelier cell axo-axonic synaptogenesis. Proceedings of the National Academy of Sciences of USA, 119 (11). e2114476119. ISSN 0027-8424 |
| DOI: | 10.1073/pnas.2114476119 |
| الإتاحة: | https://doi.org/10.1073/pnas.2114476119Test https://repository.cshl.edu/id/eprint/40552Test/ https://repository.cshl.edu/id/eprint/40552/1/2022.Gallo.axo-axonic.pdfTest https://www.ncbi.nlm.nih.gov/pubmed/35263225Test |
| حقوق: | cc_by_nc_nd |
| رقم الانضمام: | edsbas.295A5D0D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.2114476119 |
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