التفاصيل البيبلوغرافية
| العنوان: |
Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy |
| المؤلفون: |
Seo, Hee Seung, Han, Jun-Hyeok, Lim, Jaesung, Bae, Ga-Hyun, Byun, Min Ji, Wang, Chi-Pin James, Han, Jieun, Park, Juwon, Park, Hee Ho, Shin, Mikyung, Park, Tae-Eun, Kim, Tae-Hyung, Kim, Se-Na, Park, Wooram, Park, Chun Gwon |
| المساهمون: |
Ministry of Science and ICT, South Korea, Ministry of Education, Korea Institute of Science and Technology |
| المصدر: |
Biomaterials Research ; volume 28 ; ISSN 2055-7124 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2024 |
| الوصف: |
Background: Cancer recurrence and metastasis are major contributors to treatment failure following tumor resection surgery. We developed a novel implantable drug delivery system utilizing glycol chitosan to address these issues. Glycol chitosan is a natural adjuvant, inducing dendritic cell activation to promote T helper 1 cell immune responses, macrophage activation, and cytokine production. Effective antigen production by dendritic cells initiates T-cell-mediated immune responses, aiding tumor growth control. Methods: In this study, we fabricated multifunctional methacrylated glycol chitosan (MGC) hydrogels with extended release of DNA/doxorubicin (DOX) complex for cancer immunotherapy. We constructed the resection model of breast cancer to verify the anticancer effects of MGC hydrogel with DNA/DOX complex. Results: This study demonstrated the potential of MGC hydrogel with extended release of DNA/DOX complex for local and efficient cancer therapy. The MGC hydrogel was implanted directly into the surgical site after tumor resection, activating tumor-related immune cells both locally and over a prolonged period of time through immune-reactive molecules. Conclusions: The MGC hydrogel effectively suppressed tumor recurrence and metastasis while enhancing immunotherapeutic efficacy and minimizing side effects. This biomaterial-based drug delivery system, combined with cancer immunotherapy, can substantial improve treatment outcomes and patient prognosis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.34133/bmr.0008 |
| الإتاحة: |
https://doi.org/10.34133/bmr.0008Test |
| رقم الانضمام: |
edsbas.283A36EF |
| قاعدة البيانات: |
BASE |
