التفاصيل البيبلوغرافية
| العنوان: |
Higher Potential Sensitization of Cow α S1 -Casein over Goat α S1 -Casein in a Mouse Model due to Enhanced Dendritic Cell Uptake and Activation |
| المؤلفون: |
Kai Zhang, Lina Zhang, Mengyu Han, Zhiping Pu, Jinjing Zhong, Yanmei Hou, Peng Zhou |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Immunology, Developmental Biology, Cancer, Mental Health, Hematology, Biological Sciences not elsewhere classified, mouse model due, mast cell degranulation, epithelial barrier integrity, cholera toxin adjuvant, 2h3 cell model, common food allergy, milk protein α, study found differences, activation cow ’, goat milk α, higher potential sensitization, milk allergy, goat α, study aimed, investigate differences, higher production, cow α, th2 responses, th2 cells |
| الوصف: |
Cow’s milk allergy is a common food allergy, with the milk protein α S1 -casein being a major allergen. This study aimed to investigate differences in sensitization between cow and goat α S1 -CN. Cow and goat α S1 -CN were labeled with fluorescent dyes and given to mice sensitized with cholera toxin adjuvant. Both proteins reached immune organs, suggesting no major difference in digestion. However, compared with goat α S1 -CN, cow α S1 -CN is more readily taken up by dendritic cells, inducing dendritic cell maturation. Furthermore, cow α S1 -CN can more effectively induce the generation of Th2 cells, leading to a higher production of specific IgE. In a Caco-2/RBL-2H3 cell model, cow α S1 -CN caused more mast cell degranulation and loss of epithelial barrier integrity than goat α S1 -CN. In summary, this study found differences in immune responses between cow and goat milk α S1 -CN. Cow α S1 -CN elicited stronger dendritic cell and Th2 responses, leading to increased mast cell degranulation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Higher_Potential_Sensitization_of_Cow_sub_S1_sub_-Casein_over_Goat_sub_S1_sub_-Casein_in_a_Mouse_Model_due_to_Enhanced_Dendritic_Cell_Uptake_and_Activation/25077660Test |
| DOI: |
10.1021/acs.jafc.3c07688.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jafc.3c07688.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.276D81E2 |
| قاعدة البيانات: |
BASE |
