دورية أكاديمية
Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo
| العنوان: | Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo |
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| المؤلفون: | Bonzano, Sara, CRISCI, ISABELLA, Podlesny-Drabiniok, Anna, Rolando, Chiara, Krezel, Wojciech, Studer, Michèle, De Marchis, Silvia |
| المساهمون: | Bonzano, Sara, Crisci, Isabella, Podlesny-Drabiniok, Anna, Rolando, Chiara, Krezel, Wojciech, Studer, Michèle, De Marchis, Silvia |
| سنة النشر: | 2018 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | NR2F1, adult neurogenesi, astrogliogenesi, dentate gyru, neural progenitor, neural stem cell, neuroinflammation |
| الوصف: | In the dentate gyrus (DG) of the mouse hippocampus, neurogenesis and astrogliogenesis persist throughout life. Adult-born neurons and astrocytes originate from multipotent neural stem cells (NSCs) whose activity is tightly regulated within the neurogenic niche. However, the cell-intrinsic mechanisms controlling neuron-glia NSC fate choice are largely unknown. Here, we show COUP-TFI/NR2F1 expression in DG NSCs and its downregulation upon neuroinflammation. By using in vivo inducible knockout lines, a retroviral-based loss-of-function approach and genetic fate mapping, we demonstrate that COUP-TFI inactivation in adult NSCs and/or mitotic progenitors reduces neurogenesis and increases astrocyte production without depleting the NSC pool. Moreover, forced COUP-TFI expression in adult NSCs/progenitors decreases DG astrogliogenesis and rescues the neuro-astrogliogenic imbalance under neuroinflammation. Thus, COUP-TFI is necessary and sufficient to promote neurogenesis by suppressing astrogliogenesis. Our data propose COUP-TFI as a central regulator of the neuron-astroglia cell fate decision and a key modulator during neuroinflammation in the adult hippocampus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29996095; info:eu-repo/semantics/altIdentifier/wos/WOS:000438422700008; volume:24; issue:2; firstpage:329-341; lastpage:341; numberofpages:13; journal:CELL REPORTS; http://hdl.handle.net/2318/1670763Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85049300262; https://www.ncbi.nlm.nih.gov/pubmed/29996095Test |
| DOI: | 10.1016/j.celrep.2018.06.044 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2018.06.044Test http://hdl.handle.net/2318/1670763Test https://www.ncbi.nlm.nih.gov/pubmed/29996095Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.26C3A326 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2018.06.044 |
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