MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23

التفاصيل البيبلوغرافية
العنوان:	MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
المؤلفون:	Mikami Y., Philips R. L., Sciumè Giuseppe, Petermann F., Meylan F., Nagashima H., Yao C., Davis F. P., Brooks S. R., Sun H. -W., Takahashi H., Poholek A. C., Shih H. -Y., Afzali B., Muljo S. A., Hafner M., Kanno Y., O'Shea J. J.
المساهمون:	Mikami, Y., Philips, R. L., Sciumè, Giuseppe, Petermann, F., Meylan, F., Nagashima, H., Yao, C., Davis, F. P., Brooks, S. R., Sun, H. -W., Takahashi, H., Poholek, A. C., Shih, H. -Y., Afzali, B., Muljo, S. A., Hafner, M., Kanno, Y., O'Shea, J. J.
بيانات النشر:	Cell Press Cambridge, MA; USA
سنة النشر:	2021
المجموعة:	Sapienza Università di Roma: CINECA IRIS
مصطلحات موضوعية:	helper T cell, IL23r, intestine, Maf, miR-221, miR-222, miRNA, mucosal barrier damage, negative feedback, Th17
الوصف:	Mikami et al. examine the role of miR-221/222 in helper T cells in the gut. MiR-221/222 are induced by IL-23 and suppressed by TGFβ, targeting Maf and IL23r for degradation. During inflammation, these miRNAs serve as a negative feedback rheostat to constrain IL23-Th17 cell responses.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	info:eu-repo/semantics/altIdentifier/pmid/33657395; info:eu-repo/semantics/altIdentifier/wos/WOS:000627409300017; volume:54; issue:3; firstpage:514; lastpage:525.e6; numberofpages:19; journal:IMMUNITY; http://hdl.handle.net/11573/1533902Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85101966909
DOI:	10.1016/j.immuni.2021.02.015
الإتاحة:	https://doi.org/10.1016/j.immuni.2021.02.015Test http://hdl.handle.net/11573/1533902Test
حقوق:	info:eu-repo/semantics/openAccess
رقم الانضمام:	edsbas.268BDD0E
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1016/j.immuni.2021.02.015