| الوصف: |
YKL-40 is a chitinase-like glycoprotein produced by alternatively activated macrophages that are associated with wound healing and fibrosis. Asbestosis is a chronic asbestos-induced lung disease, in which injury of epithelial cells and activation of alveolar macrophages lead to enhanced collagen production and fibrosis. We studied if YKL-40 is related to inflammation, fibrosis, and/or lung function in subjects exposed to asbestosis. Venous blood samples were collected from 85 men with moderate or heavy occupational asbestos exposure and from 28 healthy, age-matched controls. Levels of plasma YKL-40, CRP, IL-6, adipsin, and MMP-9 were measured with enzyme-linked immunosorbent assay (ELISA). Plasma YKL-40 levels were significantly higher in subjects with asbestosis (n = 19) than in those with no fibrotic findings in HRCT following asbestos exposure (n = 66) or in unexposed healthy controls. In asbestos-exposed subjects, plasma YKL-40 correlated negatively with lung function capacity parameters FVC (Pearson's r −0.259, p = 0 018) and FEV 1 (Pearson's r −0.240, p = 0 028) and positively with CRP (Spearman's rho 0.371, p < 0 001), IL-6 (Spearman's rho 0.314, p = 0 003), adipsin (Spearman's rho 0.459, p < 0 001), and MMP-9 (Spearman's rho 0.243, p = 0 025). The present finding suggests YKL-40 as a biomarker associated with fibrosis and inflammation in asbestosexposed subjects. |
