دورية أكاديمية
Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab
| العنوان: | Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab |
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| المؤلفون: | BECKERS, Lien, BAETEN, Paulien, POPESCU, Veronica, SWINNEN, Dries, CARDILLI, Alessio, HAMAD, Ibrahim, VAN WIJMEERSCH, Bart, Tavernier, S.J., KLEINEWIETFELD, Markus, BROUX, Bieke, FRAUSSEN, Judith, SOMERS, Veerle |
| المساهمون: | BECKERS, Lien, BAETEN, Paulien, POPESCU, Veronica, SWINNEN, Dries, CARDILLI, Alessio, HAMAD, Ibrahim, VAN WIJMEERSCH, Bart, Tavernier, S.J., KLEINEWIETFELD, Markus, BROUX, Bieke, FRAUSSEN, Judith, SOMERS, Veerle |
| بيانات النشر: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| سنة النشر: | 2024 |
| المجموعة: | Document Server@UHasselt (Universiteit Hasselt) |
| مصطلحات موضوعية: | Multiple sclerosis, Ocrelizumab, B cells, High-dimensional flow cytometry, Treatment response, Extended interval dosing |
| الوصف: | B cell depletion by the anti-CD20 antibody ocrelizumab is effective in relapsing-remitting (RR) and primary progressive (PP) multiple sclerosis (MS). We investigated immunological changes in peripheral blood of a real- world MS cohort after 6 and 12 months of ocrelizumab. All RRMS and most PPMS patients (15/20) showed treatment response. Ocrelizumab not only reduced CD20+ B cells, but also numbers of CD20+T cells. Absolute numbers of monocytes, dendritic cells and CD8+T cells were increased, while CD56hi natural killer cells were reduced after ocrelizumab. The residual B cell population shifted towards transitional and activated, IgA+ switched memory B cells, double negative B cells, and antibody- secreting cells. Delaying the treatment interval by 2–3 months increased mean B cell frequencies and enhanced naive B cell repopulation. Ocrelizumab reduced plasma levels of interleukin(IL)-12p70 and interferon (IFN)-α2. These findings will contribute to understanding ineffective treatment responses, dealing with life-threatening infections and further unravelling MS pathogenesis. ; This work was supported by Hasselt University, Belgium, the University Foundation Belgium, and a grant from the Belgian Charcot Foundation. A.C. was supported by the Research Foundation Flanders (FWO), Belgium (Project ID 11L8322N). M.K. was supported by a SALK- grant from the government of Flanders, by an Odysseus-grant (Project ID G0G1216FWO) and senior research project (Project ID G080121N) of the FWO and by a BOF grant (ADMIRE, Project ID 21GP17BOF) from Hasselt University. The authors thank Kim Ulenaers and Igna Rutten (Hasselt University, Biomedical Research Institute and UBiLim) for helping with the sample collection and the Rehabilitation & MS Center of Noorderhart for patient recruitment. The authors would also like to thank Laura Dusaer (Hasselt University, Biomedical Research Institute), dr. Sofie Van Gassen (VIB- UGent Center for inflammation Research) and Victor Bosteels (VIB- UGent Center for inflammation Research) for ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1521-6616 |
| العلاقة: | CLINICAL IMMUNOLOGY, 259 (Art N° 109894); http://hdl.handle.net/1942/42154Test; 109894; 259; 001156782600001 |
| DOI: | 10.1016/j.clim.2024.109894 |
| الإتاحة: | https://doi.org/10.1016/j.clim.2024.109894Test http://hdl.handle.net/1942/42154Test |
| رقم الانضمام: | edsbas.25A5FEE9 |
| قاعدة البيانات: | BASE |
| تدمد: | 15216616 |
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| DOI: | 10.1016/j.clim.2024.109894 |