دورية أكاديمية
Age and dPCR can predict relapse in CML patients who discontinued imatinib: The ISAV study
| العنوان: | Age and dPCR can predict relapse in CML patients who discontinued imatinib: The ISAV study |
|---|---|
| المؤلفون: | Mori S., Vagge E., Le Coutre P., Abruzzese E., Martino B., Pungolino E., Elena C., Pierri I., Assouline S., D'Emilio A., Gozzini A., Giraldo P., Stagno F., Iurlo A., Luciani M., De Riso G., Redaelli S., Kim D. -W., Pirola A., Mezzatesta C., Petroccione A., Lodolo D'Oria A., Crivori P., Piazza R., Gambacorti-Passerini C. |
| المساهمون: | Mori, S., Vagge, E., Le Coutre, P., Abruzzese, E., Martino, B., Pungolino, E., Elena, C., Pierri, I., Assouline, S., D'Emilio, A., Gozzini, A., Giraldo, P., Stagno, F., Iurlo, A., Luciani, M., De Riso, G., Redaelli, S., Kim, D. -W., Pirola, A., Mezzatesta, C., Petroccione, A., Lodolo D'Oria, A., Crivori, P., Piazza, R., Gambacorti-Passerini, C. |
| بيانات النشر: | Wiley-Liss Inc. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA |
| سنة النشر: | 2015 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Adult, Age Factor, Aged, Female, Follow-Up Studie, Fusion Proteins, bcr-abl, Human, Imatinib Mesylate, Male, Middle Aged, Predictive Value of Test, Recurrence, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Reverse Transcriptase Polymerase Chain Reaction |
| الوصف: | Imatinib is effective for the treatment of chronic myeloid leukemia (CML). However even undetectable BCR-ABL1 by Q-RT-PCR does not equate to eradication of the disease. Digital-PCR (dPCR), able to detect 1 BCR-ABL1 positive cell out of 107, has been recently developed. The ISAV study is a multicentre trial aimed at validating dPCR to predict relapses after imatinib discontinuation in CML patients with undetectable Q-RT-PCR. CML patients under imatinib therapy since more than 2 years and with undetectable PCR for at least 18 months were eligible. Patients were monitored by standard Q-RT-PCR for 36 months. Patients losing molecular remission (two consecutive positive Q-RT-PCR with at least 1 BCR-ABL1/ABL1 value above 0.1%) resumed imatinib. The study enrolled 112 patients, with a median follow-up of 21.6 months. Fifty-two of the 108 evaluable patients (48.1%), relapsed; 73.1% relapsed in the first 9 months but 14 late relapses were observed between 10 and 22 months. Among the 56 not-relapsed patients, 40 (37.0% of total) regained Q-RT-PCR positivity but never lost MMR. dPCR results showed a significant negative predictive value ratio of 1.115 [95% CI: 1.013-1.227]. An inverse relationship between patients age and risk of relapse was evident: 95% of patients <45 years relapsed versus 42% in the class ≥45 to <65 years and 33% of patients ≥65 years [P(χ2)<0.0001]. Relapse rates ranged between 100% (<45 years, dPCR+) and 36% (>45 years, dPCR-). Imatinib can be safely discontinued in the setting of continued PCR negativity; age and dPCR results can predict relapse. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26178642; info:eu-repo/semantics/altIdentifier/wos/WOS:000362663900017; volume:90; firstpage:910; lastpage:914; numberofpages:5; journal:AMERICAN JOURNAL OF HEMATOLOGY; http://hdl.handle.net/11567/968724Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84942194839 |
| DOI: | 10.1002/ajh.24120 |
| الإتاحة: | https://doi.org/10.1002/ajh.24120Test http://hdl.handle.net/11567/968724Test |
| رقم الانضمام: | edsbas.25144F3C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ajh.24120 |
|---|