التفاصيل البيبلوغرافية
| العنوان: |
Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication |
| المؤلفون: |
Garcia-Vidal, Carolina, Iglesias-Caballero, María, Puerta-Alcalde, Pedro, Mas, Vicente, Cuesta-Chasco, Genoveva, Garcia-Pouton, Nicole, Varona, Sarai, Pozo, Francisco, Vázquez-Morón, Sonia, Marcos, Maria Angeles, Soriano, Alex, Casas, Inmaculada |
| المساهمون: |
Merck Sharp and Dohme, Pfizer |
| المصدر: |
Frontiers in Microbiology ; volume 13 ; ISSN 1664-302X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Microbiology (medical), Microbiology |
| الوصف: |
We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fmicb.2022.826883 |
| DOI: |
10.3389/fmicb.2022.826883/full |
| الإتاحة: |
https://doi.org/10.3389/fmicb.2022.826883Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.24D11A7D |
| قاعدة البيانات: |
BASE |
