دورية أكاديمية
Effect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: A Tissue Doppler Imaging Study
| العنوان: | Effect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: A Tissue Doppler Imaging Study |
|---|---|
| المؤلفون: | Kibar, Ayse Esin, Unver, Olcay, Oflaz, Mehmet Burhan, Guven, Ahmet Sami, Balli, Sevket, Ece, Ibrahim, Erdem, Sevcan, Icagasioglu, Fusun Dilara |
| المساهمون: | Kibar, Ayse Esin -- Erdem, Sevcan Mersin Womens & Childrens Hosp, Dept Pediat Cardiol, Guneykent, Mersin, Turkey -- Unver, Olcay Mersin Womens & Childrens Hosp, Dept Pediat Neurol, Mersin, Turkey -- Oflaz, Mehmet Burhan Cumhuriyet Univ, Fac Med, Dept Pediat Cardiol, Sivas, Turkey -- Guven, Ahmet Sami -- Icagasioglu, Fusun Dilara Cumhuriyet Univ, Dept Neurol, Fac Med, Sivas, Turkey -- Balli, Sevket Balikkesir Hosp, Dept Pediat Cardiol, Balikesir, Turkey -- Ece, Ibrahim Yuzuncu Yil Univ, Dept Pediat Cardiol, Fac Med, Van, Turkey, Erdem, Sevcan -- 0000-0001-5914-9166, Oflaz, Mehmet Burhan -- 0000-0003-1515-4654 |
| بيانات النشر: | SPRINGER |
| سنة النشر: | 2014 |
| المجموعة: | Sivas Cumhuriyet University Institutional Repository |
| مصطلحات موضوعية: | Antiepilepsy drugs, Echocardiography, Epilepsy, Tissue Doppler imaging, Ventricular dysfunction |
| الوصف: | WOS: 000330621300012 ; PubMed ID: 23942784 ; Impaired cardiac myocardial function may contribute to the risk for sudden unexpected death of a patient with epilepsy. This study aimed to investigate the effect of antiepilepsy drugs (AEDs) on cardiac function in pediatric epileptic patients using standard and tissue Doppler imaging (TDI) echocardiography. This hospital-based, prospective cross-sectional study investigated 52 epileptic children (mean age 9.3 +/- A 3.1 years) treated with AEDs (duration 2.4-10.0 years) and 36 healthy children (mean age 9.5 +/- A 4.0 years). In the epilepsy group, standard echocardiography showed increased left ventricular (LV) end-diastolic and end-systolic diameters, an increased LV mass index, and preserved ejection fraction. The patients also exhibited increased mitral peak A-wave velocity and mitral E-wave deceleration time as well as a decreased mitral E/A ratio. The E/Em ratio was significantly higher in the epilepsy group (5.6 +/- A 1.2) than in the control group (5.2 +/- A 1.1) (p = 0.016). In the epilepsy group, TDI showed an increased isovolumetric relaxation time and myocardial performance index (MPI). It also exhibited decreased early diastolic velocity (Em) and a decreased mitral annular displacement index in these patients. There were positive correlations between the LV lateral wall MPI (r = 0.231), septal MPI (r = 0.223), and LV mass index (p < 0.05) but no correlation with the duration of AED treatment. The authors detected subclinical ventricular dysfunction associated with AEDs at a preclinical stage. They suggest that TDI can be useful for determining the short- and long-term cardiac effects of AEDs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0172-0643 1432-1971 |
| العلاقة: | PEDIATRIC CARDIOLOGY; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1007/s00246-013-0771-8Test; https://hdl.handle.net/20.500.12418/8337Test; 35; 288; 280 |
| DOI: | 10.1007/s00246-013-0771-8 |
| الإتاحة: | https://doi.org/20.500.12418/8337Test https://doi.org/10.1007/s00246-013-0771-8Test https://hdl.handle.net/20.500.12418/8337Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.2407096D |
| قاعدة البيانات: | BASE |
| تدمد: | 01720643 14321971 |
|---|---|
| DOI: | 10.1007/s00246-013-0771-8 |