دورية أكاديمية
T-cell activation is an immune correlate of risk in BCG vaccinated infants
| العنوان: | T-cell activation is an immune correlate of risk in BCG vaccinated infants |
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| المؤلفون: | Fletcher, H, Snowden, M, Landry, B, Rida, W, Satti, I, Harris, S, Matsumiya, M, Tanner, R, O'Shea, M, Dheenadhayalan, V, Bogardus, L, Stockdale, L, Marsay, L, Chomka, A, Harrington-Kandt, R, Manjaly Thomas, Z, Naranbhai, V, Stylianou, E, Darboe, F, Penn-Nicholson, A, Nemes, E, Hatheril, M, Hussey, G, Mahomed, H, Tameris, M, McClain, J, Evans, T, Hanekom, W, Scriba, T, McShane, H |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2016 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Vaccines to protect against tuberculosis (TB) are urgently needed. We performed a case–control analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin (BCG) immunized infants from the MVA85A efficacy trial. Among 53 TB case infants and 205 matched controls, the frequency of activated HLA-DR+ CD4+ T cells associates with increased TB disease risk (OR=1.828, 95% CI=1.25–2.68, P=0.002, FDR=0.04, conditional logistic regression). In an independent study of Mycobacterium tuberculosis-infected adolescents, activated HLA-DR+ CD4+ T cells also associate with increased TB disease risk (OR=1.387, 95% CI=1.068–1.801, P=0.014, conditional logistic regression). In infants, BCG-specific T cells secreting IFN-γ associate with reduced risk of TB (OR=0.502, 95% CI=0.29–0.86, P=0.013, FDR=0.14). The causes and impact of T-cell activation on disease risk should be considered when designing and testing TB vaccine candidates for these populations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:fe3bd046-599f-415e-80b4-c8be2d9c6ceeTest; https://doi.org/10.1038/ncomms11290Test |
| DOI: | 10.1038/ncomms11290 |
| الإتاحة: | https://doi.org/10.1038/ncomms11290Test https://ora.ox.ac.uk/objects/uuid:fe3bd046-599f-415e-80b4-c8be2d9c6ceeTest |
| حقوق: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.2406474E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ncomms11290 |
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