دورية أكاديمية
Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial
| العنوان: | Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial |
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| المؤلفون: | Valgimigli, Marco, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Rothenbühler, Martina, Tebaldi, Matteo, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Rubartelli, Paolo, Briguori, Carlo, Andó, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, de Cesare, Nicoletta, Tosi, Paolo, van ‘t Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, Heg, Dik, Jüni, Peter, Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Presbitero, Patrizia, Zavalloni-Parenti, Dennis, Ferrari, Fabio, Ceravolo, Roberto, Tarantino, Fabio, Pasquetto, Giampaolo, Casu, Gavino, Mameli, Stefano, Stochino, Maria Letizia, Mazzarotto, Pietro, Cremonesi, Alberto, Saia, Francesco, Saccone, Giovanni, Abate, Fabio, Picchi, Andrea, Violini, Roberto, Colangelo, Salvatore, Boccuzzi, Giacomo, Guiducci, Vincenzo, Vigna, Carlo, Zingarelli, Antonio, Gagnor, Andrea, Zaro, Tiziana, Tresoldi, Simone, Vandoni, Pietro, Contarini, Marco, Liso, Armando, Dellavalle, Antonio, Curello, Salvatore, Mangiacapra, Fabio, Evola, Rosario, Palmieri, Cataldo, Falcone, Camillo, Liistro, Francesco, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Perkan, Andrea, De Servi, Stefano, Fischetti, Dionigi, Rigattieri, Stefano, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, De Caterina, Raffaele, Caputo, Marcello, Zimmarino, Marco, Bramucci, Ezio, Di Lorenzo, Emilio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Loi, Bruno, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Micari, Antonio, Belloni, Flavia, Amico, Francesco, Comeglio, Marco, Fresco, Claudio, Klinieken, Isala, Van Mieghem, Nicolas, Diletti, Roberto, Regar, Evelyn, Sabaté, Manel, Gómez Hospital, Joan Antoni, Díaz Fernández, José Francisco, Mainar, Vicente, de la Torre Hernandez, Jose Maria |
| المساهمون: | Valgimigli, Marco, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Rothenbühler, Martina, Tebaldi, Matteo, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Rubartelli, Paolo, Briguori, Carlo, Andó, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, de Cesare, Nicoletta, Tosi, Paolo, van ‘t Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, Heg, Dik, Jüni, Peter, Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Presbitero, Patrizia, Zavalloni-Parenti, Denni, Ferrari, Fabio, Ceravolo, Roberto, Tarantino, Fabio, Pasquetto, Giampaolo, Casu, Gavino, Mameli, Stefano, Stochino, Maria Letizia, Mazzarotto, Pietro, Cremonesi, Alberto, Saia, Francesco, Saccone, Giovanni, Abate, Fabio, Picchi, Andrea, Violini, Roberto, Colangelo, Salvatore, Boccuzzi, Giacomo, Guiducci, Vincenzo, Vigna, Carlo, Zingarelli, Antonio, Gagnor, Andrea, Zaro, Tiziana, Tresoldi, Simone, Vandoni, Pietro, Contarini, Marco, Liso, Armando, Dellavalle, Antonio, Curello, Salvatore, Mangiacapra, Fabio, Evola, Rosario, Palmieri, Cataldo, Falcone, Camillo, Liistro, Francesco, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Perkan, Andrea, De Servi, Stefano, Fischetti, Dionigi, Rigattieri, Stefano, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, De Caterina, Raffaele, Caputo, Marcello, Zimmarino, Marco, Bramucci, Ezio, Di Lorenzo, Emilio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Loi, Bruno, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Micari, Antonio, Belloni, Flavia, Amico, Francesco, Comeglio, Marco, Fresco, Claudio |
| سنة النشر: | 2018 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Acute Coronary Syndrome, Aged, Anticoagulant, Antithrombin, Coronary Angiography, Female, Hemorrhage, Heparin, Hirudin, Human, Male, Middle Aged, Mortality, Myocardial Infarction, Peptide Fragment, Percutaneous Coronary Intervention, Perioperative Care, Platelet Glycoprotein GPIIb-IIIa Complex, Prosthesis Failure, Recombinant Protein, Stent, Stroke, Femoral Artery, Radial Artery, Medicine (all) |
| الوصف: | Background: The Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox (MATRIX) programme was designed to assess the comparative safety and effectiveness of radial versus femoral access and of bivalirudin versus unfractionated heparin with optional glycoprotein IIb/IIIa inhibitors in patients with the whole spectrum of acute coronary syndrome undergoing invasive management. Here we describe the prespecified final 1-year outcomes of the entire programme. Methods: MATRIX was a programme of three nested, randomised, multicentre, open-label, superiority trials in patients with acute coronary syndrome in 78 hospitals in Italy, the Netherlands, Spain, and Sweden. Patients with ST-elevation myocardial infarction were simultaneously randomly assigned (1:1) before coronary angiography to radial or femoral access and to bivalirudin, with or without post-percutaneous coronary intervention infusion or unfractionated heparin (one-step inclusion). Patients with non-ST-elevation acute coronary syndrome were randomly assigned (1:1) before coronary angiography to radial or femoral access and, only if deemed eligible to percutaneous coronary intervention after angiography (two-step inclusion), entered the antithrombin type and treatment duration programmes. Randomisation sequences were computer generated, blocked, and stratified by intended new or current use of P2Y12 inhibitor (clopidogrel vs ticagrelor or prasugrel), and acute coronary syndrome type (ST-elevation myocardial infarction, troponin-positive, or troponin-negative non-ST-elevation acute coronary syndrome). Bivalirudin was given as a bolus of 0·75 mg/kg, followed immediately by an infusion of 1·75 mg/kg per h until completion of percutaneous coronary intervention. Heparin was given at 70–100 units per kg in patients not receiving glycoprotein IIb/IIIa inhibitors, and at 50–70 units per kg in patients receiving glycoprotein IIb/IIIa inhibitors. Clinical follow-up was done at 30 days and 1 year. Co-primary outcomes for ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30153988; volume:392; issue:10150; firstpage:835; lastpage:848; numberofpages:14; journal:THE LANCET; http://hdl.handle.net/11568/937247Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85053817662; http://www.journals.elsevier.com/the-lancetTest/ |
| DOI: | 10.1016/S0140-6736(18)31714-8 |
| الإتاحة: | https://doi.org/10.1016/S0140-6736Test(18)31714-8 http://hdl.handle.net/11568/937247Test http://www.journals.elsevier.com/the-lancetTest/ |
| رقم الانضمام: | edsbas.23F2617D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0140-6736(18)31714-8 |
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