دورية أكاديمية
Changes in critically ill cancer patients’ short-term outcome over the last decades:results of systematic review with meta-analysis on individual data
| العنوان: | Changes in critically ill cancer patients’ short-term outcome over the last decades:results of systematic review with meta-analysis on individual data |
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| المؤلفون: | Darmon, Michaël, Bourmaud, Aurélie, Georges, Quentin, Soares, Marcio, Jeon, Kyeongman, Oeyen, Sandra, Rhee, Chin Kook, Gruber, Pascale, Ostermann, Marlies, Hill, Quentin A., Depuydt, Pieter, Ferra, Christelle, Toffart, Anne Claire, Schellongowski, Peter, Müller, Alice, Lemiale, Virginie, Mokart, Djamel, Azoulay, Elie |
| المصدر: | Darmon , M , Bourmaud , A , Georges , Q , Soares , M , Jeon , K , Oeyen , S , Rhee , C K , Gruber , P , Ostermann , M , Hill , Q A , Depuydt , P , Ferra , C , Toffart , A C , Schellongowski , P , Müller , A , Lemiale , V , Mokart , D & Azoulay , E 2019 , ' Changes in critically ill cancer patients’ short-term outcome over the last decades : results of systematic review with meta-analysis on individual data .... |
| سنة النشر: | 2019 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Hematologic neoplasms, Intensive care units, Mechanical ventilation, Neutropenia, Outcomes, Prognosis |
| الوصف: | Purpose: The number of averted deaths due to therapeutic advances in oncology and hematology is substantial and increasing. Survival of critically ill cancer patients has also improved during the last 2 decades. However, these data stem predominantly from unadjusted analyses. The aim of this study was to assess the impact of ICU admission year on short-term survival of critically ill cancer patients, with special attention on those with neutropenia. Methods: Systematic review and meta-analysis of individual data according to the guidelines of meta-analysis of observational studies in epidemiology. Datasource: Pubmed and Cochrane databases. Eligibility criteria: Adult studies published in English between May 2005 and May 2015. Results: Overall, 7354 patients were included among whom 1666 presented with neutropenia at ICU admission. Median ICU admission year was 2007 (IQR 2004–2010; range 1994–2012) and median number of admissions per year was 693 (IQR 450–1007). Overall mortality was 47.7%. ICU admission year was associated with a progressive decrease in hospital mortality (OR per year 0.94; 95% CI 0.93–0.95). After adjustment for confounders, year of ICU admission was independently associated with hospital mortality (OR for hospital mortality per year: 0.96; 95% CI 0.95–0.97). The association was also seen in patients with neutropenia but not in allogeneic stem cell transplant recipients. Conclusion: After adjustment for patient characteristics, severity of illness and clustering, hospital mortality decreased steadily over time in critically ill oncology and hematology patients except for allogeneic stem cell transplant recipients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00134-019-05653-7 |
| الإتاحة: | https://doi.org/10.1007/s00134-019-05653-7Test https://kclpure.kcl.ac.uk/portal/en/publications/b7363814-c4d6-4848-ab95-4c86ff88889aTest http://www.scopus.com/inward/record.url?scp=85068802557&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.239D2FDD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00134-019-05653-7 |
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