دورية أكاديمية
The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study
| العنوان: | The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study |
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| المؤلفون: | Warncke, Katharina, Tamura, Roy, Schatz, Desmond A, Veijola, Riitta, Steck, Andrea K, Akolkar, Beena, Hagopian, William, Krischer, Jeffrey P, Lernmark, Åke, Rewers, Marian J, Toppari, Jorma, McIndoe, Richard, Ziegler, Anette-G, Vehik, Kendra, Haller, Michael J, Elding Larsson, Helena |
| المصدر: | Journal of the Endocrine Society; 8(7), no bvae103 (2024) ; ISSN: 2472-1972 |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2024 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Endocrinology and Diabetes |
| الوصف: | CONTEXT: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty.OBJECTIVE: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes.METHODS: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Onset of puberty was determined by subject self-assessment of Tanner stages. Associations between speed of pubertal progression, pubertal growth, weight gain, homeostasis model assessment of insulin resistance (HOMA-IR), islet autoimmunity, and progression to type 1 diabetes were assessed. The influence of individual factors was analyzed using Cox proportional hazard ratios.RESULTS: Out of 5677 children who were still in the study at age 8 years, 95% reported at least 1 Tanner Stage score and were included in the study. Children at puberty (Tanner Stage ≥2) had a lower risk (HR 0.65, 95% CI 0.45-0.93; P = .019) for incident autoimmunity than prepubertal children (Tanner Stage 1). An increase of body mass index Z-score was associated with a higher risk (HR 2.88, 95% CI 1.61-5.15; P < .001) of incident insulin autoantibodies. In children with multiple autoantibodies, neither HOMA-IR nor rate of progression to Tanner Stage 4 were associated with progression to type 1 diabetes. CONCLUSION: Rapid weight gain during puberty is associated with development of islet autoimmunity. Puberty itself had no significant influence on the appearance of autoantibodies or type 1 diabetes. Further studies are needed to better understand the underlying mechanisms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/48857c52-2d41-4031-9561-da1bc0cb4f40Test; http://dx.doi.org/10.1210/jendso/bvae103Test; pmid:38867880 |
| DOI: | 10.1210/jendso/bvae103 |
| الإتاحة: | https://doi.org/10.1210/jendso/bvae103Test https://lup.lub.lu.se/record/48857c52-2d41-4031-9561-da1bc0cb4f40Test |
| رقم الانضمام: | edsbas.23985941 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jendso/bvae103 |
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