دورية أكاديمية
Free fatty acids decrease circulating ghrelin concentrations in humans
| العنوان: | Free fatty acids decrease circulating ghrelin concentrations in humans |
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| المؤلفون: | Gormsen, Lars C, Gjedsted, Jakob, Gjedde, Signe, Vestergaard, Esben Thyssen, Christiansen, Jens S, Jørgensen, Jens Otto, Nielsen, Søren, Møller, Niels |
| المصدر: | European Journal of Endocrinology ; volume 154, issue 5, page 667-673 ; ISSN 0804-4643 1479-683X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism |
| الوصف: | Objective : Concentrations of the orexigenic peptide ghrelin is affected by a number of hormones, which also affect circulating levels of free fatty acids (FFAs). The present study was therefore designed to determine the direct effect of FFAs on circulating ghrelin. Design : Eight lean, healthy men were examined for 8 h on four occasions using variable infusion rates (0, 3, 6 and 12 μl/kg per min) of intralipid to create different plasma FFA concentrations. Constant levels of insulin and GH were obtained by administration of acipimox (250 mg) and somatostatin (300 μg/h). At the end of each study day a hyperinsulinaemic-euglycaemic clamp was performed. Results : Four distinct levels of FFAs were obtained at the end of the lipid infusion period (FFA LIPID : 0.03 ± 0.00 vs: 0.49 ± 0.04, 0.92 ± 0.08 and 2.09 ± 0.38 mmol/l; ANOVA P < 0.0001) and during hyperinsulinaemia (FFA LIPID+INSULIN : 0.02 ± 0.00 vs: 0.34 ± 0.03, 0.68 ± 0.09 and 1.78 ± 0.32 mmol/l; ANOVA P < 0.0001). Whereas, somatostatin infusion alone reduced ghrelin concentration by ~67%, concomitant administration of increasing amounts of intralipid reduced circulating ghrelin by a further 14, 19 and 19% respectively (change in ghrelin: 0.52 ± 0.05 vs: 0.62 ± 0.06, 0.72 ± 0.09 and 0.71 ± 0.05 μg/l; ANOVA P = 0.04). No further reduction in ghrelin concentration was observed during hyperinsulinaemia. Conclusion : FFA exposure between 0 and 1 mmol/l significantly suppresses ghrelin levels independent of ambient GH and insulin levels. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/eje.1.02146 |
| الإتاحة: | https://doi.org/10.1530/eje.1.02146Test https://eje.bioscientifica.com/view/journals/eje/154/5/1540667.xmlTest |
| رقم الانضمام: | edsbas.238197DB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/eje.1.02146 |
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