التفاصيل البيبلوغرافية
| العنوان: |
Contribution of a genetic risk score to ethnic differences in fatty liver disease |
| المؤلفون: |
Kubiliun, Maddie J., Cohen, Jonathan C., Hobbs, Helen H., Kozlitina, Julia |
| المساهمون: |
National Institute of Diabetes and Digestive and Kidney Diseases |
| المصدر: |
Liver International ; volume 42, issue 10, page 2227-2236 ; ISSN 1478-3223 1478-3231 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2022 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background and aims Susceptibility to fatty liver disease (FLD) varies among individuals and between racial/ethnic groups. Several genetic variants influence FLD risk, but whether these variants explain racial/ethnic differences in FLD prevalence is unclear. We examined the contribution of genetic risk factors to racial/ethnic‐specific differences in FLD. Methods A case–control study comparing FLD patients ( n = 1194) and population‐based controls ( n = 3120) was performed. Patient characteristics, FLD risk variants ( PNPLA3‐ rs738409 + rs6006460, TM6SF2‐ rs58542926, HSD17B13‐ rs80182459 + rs72613567, MBOAT7 / TMC4‐ rs641738, and GCKR‐ rs1260326) and a multi‐locus genetic risk score (GRS) were examined. The odds of FLD for individuals with different risk factor burdens were determined. Results Hispanics and Whites were over‐represented (56% vs. 38% and 36% vs. 29% respectively) and Blacks under‐represented (5% vs. 23%) among FLD patients, compared to the population from which controls were selected ( p < .001). Among cases and controls, Blacks had a lower and Hispanics a greater, net number of risk alleles than Whites ( p < .001). GRS was associated with increased odds of FLD (OR Q5vsQ1 = 8.72 [95% CI = 5.97–13.0], p = 9.8 × 10 −28 ), with the association being stronger in Hispanics (OR Q5vsQ1 = 14.8 [8.3–27.1]) than Blacks (OR Q5vsQ1 = 3.7 [1.5–11.5], P‐interaction = 0.002). After accounting for GRS, the odds of FLD between Hispanics and Whites did not differ significantly (OR = 1.06 [0.87–1.28], p = .58), whereas Blacks retained much lower odds of FLD (OR = 0.21, [0.15–0.30], p < .001). Conclusions Blacks had a lower and Hispanics a greater FLD risk allele burden than Whites. These differences contributed to, but did not fully explain, racial/ethnic differences in FLD prevalence. Identification of additional factors protecting Blacks from FLD may provide new targets for prevention and treatment of FLD. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/liv.15322 |
| الإتاحة: |
https://doi.org/10.1111/liv.15322Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.2345D184 |
| قاعدة البيانات: |
BASE |
