التفاصيل البيبلوغرافية
| العنوان: |
A case of allogeneic peripheral blood stem cell in a paroxysmal nocturnal hemoglobinuria patient from a COVID-positive donor: Managing the unpreventable |
| المؤلفون: |
Chowdhry, Mohit, Singh, Prachi, Lekshmi, S Minu, Thakur, Uday Kumar, Seth, Shishir |
| المصدر: |
Asian Journal of Transfusion Science ; ISSN 0973-6247 1998-3565 |
| بيانات النشر: |
Medknow |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Hematology, Immunology and Allergy |
| الوصف: |
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease caused by clonal expansion of one or more hematopoietic stem cell lines due to a somatic mutation of the phosphatidylinositol glycan anchor gene. Peripheral blood stem cell (PBSC) harvest is a high-risk procedure and the major concern was regarding the development of COVID infection in the recipient. Herein, we describe an inevitable case of PBSC harvest in a PNH patient who was already started on myeloablation and where the donor became positive 1 day before the harvest. Considering the risk–benefit ratio and the need for elaborate arrangements, the initial plan for bone marrow harvesting was changed to PBSC, and hence, the harvest was performed in a COVID-designated unit. No features of graft versus host disease (GVHD) were observed in the patient. The patient was examined for signs and symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and there was no evidence of any infection after the procedure. The weekly analysis of the same was done for 1 month after PBSC and the SARS-CoV-2 status remained negative. The authors opine that PBSC from SARS-CoV-2 can be performed safely in some unpreventable situations. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.4103/ajts.ajts_57_23 |
| الإتاحة: |
https://doi.org/10.4103/ajts.ajts_57_23Test |
| رقم الانضمام: |
edsbas.233EC86C |
| قاعدة البيانات: |
BASE |
