دورية أكاديمية
6-Month Versus 12-Month Dual-Antiplatelet Therapy Following Long Everolimus-Eluting Stent Implantation: The IVUS-XPL Randomized Clinical Trial.
| العنوان: | 6-Month Versus 12-Month Dual-Antiplatelet Therapy Following Long Everolimus-Eluting Stent Implantation: The IVUS-XPL Randomized Clinical Trial. |
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| المساهمون: | College of Medicine, Dept. of Internal Medicine, Sung-Jin Hong, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Ae-Young Her, Yong Hoon Kim, Yangsoo Jang, Myeong-Ki Hong, the IVUS-XPL Investigators, Ko, Young Guk, Kim, Byeong Keuk, Kim, Jung Sun, Shin, Dong Ho, Jang, Yang Soo, Choi, Dong Hoon, Hong, Myeong Ki |
| بيانات النشر: | Elsevier United States |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Aspirin/administration & dosage, Aspirin/adverse effects, Cardiovascular Agents/administration & dosage, Cardiovascular Agents/adverse effects, Coronary Thrombosis/etiology, Drug Administration Schedule, Drug Therapy, Combination, Drug-Eluting Stents, Everolimus/administration & dosage, Everolimus/adverse effects, Hemorrhage/chemically induced, Humans, Intention to Treat Analysis, Myocardial Infarction/etiology, Percutaneous Coronary Intervention/adverse effects, Percutaneous Coronary Intervention/instrumentation, Percutaneous Coronary Intervention/mortality, Platelet Aggregation Inhibitors/administration & dosage, Platelet Aggregation Inhibitors/adverse effects, Prosthesis Design, Republic of Korea, Risk Factors, Stroke/etiology, Ticlopidine/administration & dosage, Ticlopidine/adverse effects, Ticlopidine/analogs & derivatives, Time Factors, Treatment Outcome, coronary artery disease |
| الوصف: | OBJECTIVES: The aim of this study was to investigate whether a 6-month dual-antiplatelet therapy (DAPT) duration was comparable with a 12-month duration in patients who underwent everolimus-eluting stent implantation. BACKGROUND: Well-designed studies that determine optimal DAPT strategies after everolimus-eluting stent implantation are limited. METHODS: A total of 1,400 patients (implanted mean total stent length >45 mm) were randomly assigned to receive 6-month (n = 699) or 12-month (n = 701) DAPT between October 2010 and July 2014 at 20 centers in Korea. The primary endpoint was the composite of cardiac death, myocardial infarction, stroke, or TIMI (Thrombolysis in Myocardial Infarction) major bleeding at 1 year, analyzed using an intention-to-treat approach. RESULTS: The primary endpoint occurred in 15 patients (2.2%) in the 6-month DAPT group and 14 patients (2.1%) in the 12-month DAPT group (hazard ratio [HR]: 1.07; p = 0.854). Definite or probable stent thrombosis occurred in 2 patients (0.3%) in the 6-month DAPT group and in 2 patients (0.3%) in the 12-month DAPT group (HR: 1.00; p = 0.999). There were no significant between-group differences in the primary endpoint in 686 patients with acute coronary syndrome (2.4% in both groups; HR: 1.00; p = 0.994) and in 506 patients with diabetes mellitus (2.2% [6-month] vs. 3.3% [12-month]; HR: 0.64; p = 0.428). CONCLUSIONS: Compared with 12-month DAPT, 6-month DAPT did not increase the composite events of cardiac death, myocardial infarction, stroke, or TIMI major bleeding at 1 year in patients who underwent everolimus-eluting stent implantation. (Impact of Intravascular Ultrasound Guidance on Outcomes of XIENCE PRIME Stents in Long Lesions [IVUS-XPL Study]; NCT01308281). ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1438~1446 |
| اللغة: | English |
| ردمك: | 978-1-936879-81-6 1-936879-81-6 |
| تدمد: | 1936-8798 1876-7605 |
| العلاقة: | JACC-CARDIOVASCULAR INTERVENTIONS; J01193; OAK-2016-03285; https://ir.ymlib.yonsei.ac.kr/handle/22282913/147133Test; http://www.sciencedirect.com/science/article/pii/S1936879816304897Test; T201602141; JACC-CARDIOVASCULAR INTERVENTIONS, Vol.9(14) : 1438-1446, 2016 |
| DOI: | 10.1016/j.jcin.2016.04.036 |
| الإتاحة: | https://doi.org/10.1016/j.jcin.2016.04.036Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/147133Test http://www.sciencedirect.com/science/article/pii/S1936879816304897Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.2324DB1F |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9781936879816 1936879816 |
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| تدمد: | 19368798 18767605 |
| DOI: | 10.1016/j.jcin.2016.04.036 |