دورية أكاديمية
Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease The Kompas Randomized Clinical Trial
| العنوان: | Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease The Kompas Randomized Clinical Trial |
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| المؤلفون: | Timal, Rohit J., Kooiman, Judith, Sijpkens, Yvo W. J., de Vries, Jean-Paul P. M., Verberk-Jonkers, Iris J. A. M., Brulez, Harald F. H., van Buren, Marjolijn, van der Molen, Aart J., Cannegieter, Suzanne C., Putter, Hein, van den Hout, Wilbert B., Jukema, J. Wouter, Rabelink, Ton J., Huisman, Menno V. |
| المصدر: | Timal , R J , Kooiman , J , Sijpkens , Y W J , de Vries , J-P P M , Verberk-Jonkers , I J A M , Brulez , H F H , van Buren , M , van der Molen , A J , Cannegieter , S C , Putter , H , van den Hout , W B , Jukema , J W , Rabelink , T J & Huisman , M V 2020 , ' Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute .... |
| سنة النشر: | 2020 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | SERUM CREATININE CHANGES, INDUCED NEPHROPATHY, RENAL-FUNCTION, HYDRATION, RISK, ACETYLCYSTEINE, METAANALYSIS, DEFINITION, SALINE |
| الوصف: | Importance Prevention of postcontrast acute kidney injury in patients with stage 3 chronic kidney disease (CKD) by means of prehydration has been standard care for years. However, evidence for the need for prehydration in this group is limited. Objective To assess the renal safety of omitting prophylactic prehydration prior to iodine-based contrast media administration in patients with stage 3 CKD. Design, Setting, and Participants The Kompas trial was a multicenter, noninferiority, randomized clinical trial conducted at 6 hospitals in the Netherlands in which 523 patients with stage 3 CKD were randomized in a 1:1 ratio to receive no prehydration or prehydration with 250 mL of 1.4% sodium bicarbonate administered in a 1-hour infusion before undergoing elective contrast-enhanced computed tomography from April 2013 through September 2016. Final follow-up was completed in September 2017. Data were analyzed from January 2018 to June 2019. Interventions In total, 262 patients were allocated to the no prehydration group and 261 were allocated to receive prehydration. Analysis on the primary end point was available in 505 patients (96.6%). Main Outcomes and Measures The primary end point was the mean relative increase in serum creatinine level 2 to 5 days after contrast administration compared with baseline (noninferiority margin of less than 10% increase in serum creatinine level). Secondary outcomes included the incidence of postcontrast acute kidney injury 2 to 5 days after contrast administration, mean relative increase in creatinine level 7 to 14 days after contrast administration, incidences of acute heart failure and renal failure requiring dialysis, and health care costs. Results Of 554 patients randomized, 523 were included in the intention-to-treat analysis. The median (interquartile range) age was 74 (67-79) years; 336 (64.2%) were men and 187 (35.8%) were women. The mean (SD) relative increase in creatinine level 2 to 5 days after contrast administration compared with baseline was 3.0% (10.5) in the no ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/622f4f3c-ad05-44cd-b7fa-b66fe936b388Test |
| DOI: | 10.1001/jamainternmed.2019.7428 |
| الإتاحة: | https://doi.org/10.1001/jamainternmed.2019.7428Test https://hdl.handle.net/11370/622f4f3c-ad05-44cd-b7fa-b66fe936b388Test https://research.rug.nl/en/publications/622f4f3c-ad05-44cd-b7fa-b66fe936b388Test https://pure.rug.nl/ws/files/146353419/jamainternal_timal_2020_oi_190116_2_.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.23123302 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamainternmed.2019.7428 |
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