التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of Taxifolin in The Prevention of Renal Injury Due to Liver Ischemia and Reperfusion ; KARACİĞER İSKEMİ VE REPERFÜZYONA BAĞLI BÖBREK HASARLARININ ÖNLENMESİNDE TAKSİFOLİN’İN ETKİNLİĞİ |
| المؤلفون: |
ÜLGER, Burak Veli, AŞIR, Fırat, VARLI, Metin, GÜNDÜZ, Ercan, DURGUN, Hasan Mansur |
| المصدر: |
Volume: 6, Issue: 3 503-507 ; 2667-498X ; Journal of Cukurova Anesthesia and Surgical Sciences ; Çukurova Anestezi ve Cerrahi Bilimler Dergisi |
| بيانات النشر: |
Merthan TUNAY |
| سنة النشر: |
2023 |
| المجموعة: |
DergiPark Akademik (E-Journals) |
| مصطلحات موضوعية: |
liver ischemia and reperfusion, taxifolin, histopathology, immunohistochemistry, oxidative stress, Karaciğer iskemi ve reperfüzyon, Taksifolin, Histopatoloji, İmmunohistokimya, Oksidatif stres, General Surgery, Genel Cerrahi, Pathology, Patoloji |
| الوصف: |
Aim: During surgical procedures such as liver resection and transplantation, ischemia/reperfusion (I/R) injury and related complications may occur at a rate of approximately 10%. Our study, we planned to investigate histologically and biochemically the efficacy of Taxifolin in the prevention of renal tissue damage in liver ischemia reperfusion.Methods: A total of 28 Wistar Albino rats with an average age of 8-10 weeks and weights of 250-300 grams were used in our study. Group 1 (n=7): control group, Group 2 (n=7): Taxifolin group; Taxifolin was administered orally at a dose of 50 mg/kg for 3 weeks, Group 3 (n=7): Liver I/R group, 30 minutes ischemia and 120 minutes reperfusion was performed. Group 4 (n=7): Taxifolin+Liver I/R group.Results: Kidney tissues of the liver I/R group showed atrophy, degeneration of tubule epithelium and increased TNF-α expression. In addition, deterioration in renal function tests was also monitored in this group. In the Taxifolin+Liver I/R group, a significant difference was observed on both histologic and biochemical basis compared to the Liver I/R group and a positive effect was observed (p<0.05).Outcome: As a consequence of hepatic ischemia and reperfusion, impairment in the function and histological appearance of renal tissues was observed and Taxifolin was monitored to be effective in eliminating these adverse effects. ; Amaç: Karaciğer rezeksiyonu ve transplantasyonu gibi cerrahi işlemler sırasında yaklaşık gibi bir oranda iskemi/reperfüzyon (I/R) hasarı gibi ciddi komplikasyonlar görülebilmektedir. Bu çalışmada böylesi bir komplikasyonun karaciğer dışında böbrek dokusu gibi bir organda meydana getireceği hasarın düzeltilmesinde Taksifolin’in etkinliğini histolojik ve biyokimyasal açıdan incelemeyi planladık.Yöntem: Çalışmamızda ortalama 8-10 haftalık, 250-300 gram ağırlıklarında toplam 28 adet Wistar Albino cinsi ratlar kullandı. Grup 1 (n=7): kontrol grubu, Grup 2 (n=7): Taksifolin grubu olup 50 mg/kg doz ile oral yoldan 3 hafta süreyle, Grup 3 (n=7): Karaciğer I/R ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dergipark.org.tr/tr/download/article-file/3456813Test; https://dergipark.org.tr/tr/pub/jocass/issue/80236/1371823Test |
| الإتاحة: |
https://dergipark.org.tr/tr/pub/jocass/issue/80236/1371823Test |
| رقم الانضمام: |
edsbas.227E4B75 |
| قاعدة البيانات: |
BASE |
