دورية أكاديمية
Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity
| العنوان: | Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity |
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| المؤلفون: | Heras, Andrea, Gomi, Rika, Young, Madeline, Chang, Chuchun L., Wasserman, Emily, Sharma, Anurag, Wu, Wenzhu, Gu, Jinghua, Balaji, Uthra, White, Rachel, Permaul, Perdita, Janahi, Ibrahim, Worgall, Tilla S., Worgall, Stefan |
| المساهمون: | National Institutes of Health, Qatar National Research Fund |
| المصدر: | Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients that can affect inflammatory responses. While n-3 PUFAs are generally considered beneficial for cardiovascular disease and obesity, the effects on asthma, the most common inflammatory lung disease are unclear. While prenatal dietary n-3 PUFAs decrease the risk for childhood wheezing, postnatal dietary n-3 PUFAs can worsen allergic airway inflammation. Sphingolipid metabolism is also affected by dietary n-3 PUFAs. Decreased sphingolipid synthesis leads to airway hyperreactivity, besides inflammation, a cardinal feature of asthma, and common genetic asthma risk alleles lead to lower sphingolipid synthesis. We investigated the effect of dietary n-3 PUFAs on sphingolipid metabolism and airway reactivity. Comparing a fish-oil diet with a high n-3 PUFA content (FO) to an isocaloric coconut oil-enriched diet (CO), we found an n-3 PUFA-dependent effect on increased airway reactivity, that was not accompanied by inflammation. Lung and whole blood content of dihydroceramides, ceramides, sphingomyelins, and glucosylceramides were lower in mice fed the n-3 PUFA enriched diet consistent with lower sphingolipid synthesis. In contrast, phosphorylated long chain bases such as sphingosine 1-phosphate were increased. These findings suggest that dietary n-3 PUFAs affect pulmonary sphingolipid composition to favor innate airway hyperreactivity, independent of inflammation, and point to an important role of n-3 PUFAs in sphingolipid metabolism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-022-21083-w |
| الإتاحة: | https://doi.org/10.1038/s41598-022-21083-wTest https://www.nature.com/articles/s41598-022-21083-w.pdfTest https://www.nature.com/articles/s41598-022-21083-wTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.22614CB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-022-21083-w |
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