دورية أكاديمية
DNA methylation-based profiling of horse archaeological remains for age-at-death and castration
| العنوان: | DNA methylation-based profiling of horse archaeological remains for age-at-death and castration |
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| المؤلفون: | Liu, Xuexue, Seguin- Orlando, Andaine, Chauvey, Lorelei, Tressières, Gaëtan, Tonasso-Calvie, Laure, Aury, Jean-Marc, Perdereau, Aude, Wagner, Stefanie, Clavel, Pierre, Estrada, Oscar, Pan, Jianfei, Ma, Yuehui, Enk, Jacob, Devault, Alison, Klunk, Jennifer, Clavel, Benoit, Jiang, Lin, Wincker, Patrick, Collin, Yvette, Running Horse, Der Sarkissian, Clio, Orlando, Ludovic, Lepetz, Sébastien, Schiavinato, Stéphanie |
| المساهمون: | Centre d'anthropologie et de génomique de Toulouse (CAGT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioinformatique pour la Génomique et la Biodiversité (LBGB), Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage Evry (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS)-Genoscope - Centre national de séquençage Evry (GENOSCOPE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département écologie et biodiversité des milieux forestiers, prairiaux et aquatiques (ECODIV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Chinese Academy of Agricultural Sciences (CAAS), Daicel Arbor Biosciences Ann Arbor, MI, Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), ANR-10-INBS-0009,France Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), European Project: 681605,PEGASUS, European Project: 101027750,HOPE, European Project: 890702,MethylRIDE |
| المصدر: | EISSN: 2589-0042 ; iScience ; https://cea.hal.science/cea-04286440Test ; iScience, 2023, 26 (3), pp.106144. ⟨10.1016/j.isci.2023.106144⟩ ; https://www.sciencedirect.com/science/article/pii/S2589004223002213Test |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], [SDV.BA]Life Sciences [q-bio]/Animal biology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory |
| الوصف: | International audience ; Age profiling of archaeological bone assemblages can inform on past animal management practices, but is limited by the fragmentary nature of the fossil record and the lack of universal skeletal markers for age. DNA methylation clocks offer new, albeit challenging, alternatives for estimating the age-at-death of ancient individuals. Here, we take advantage of the availability of a DNA methylation clock based on 31,836 CpG sites and dental age markers in horses to assess age predictions in 84 ancient remains. We evaluate our approach using whole-genome sequencing data and develop a capture assay providing reliable estimates for only a fraction of the cost. We also leverage DNA methylation patterns to assess castration practice in the past. Our work opens for a deeper characterization of past husbandry and ritual practices and holds the potential to reveal age mortality profiles in ancient societies, once extended to human remains. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36843848; info:eu-repo/grantAgreement//681605/EU/The makeup of the modern horse: a history of the biological changes introduced by human management/PEGASUS; info:eu-repo/grantAgreement//101027750/EU/Unveiling the true historical and biological origins of key phenotypes in modern domestic horses/HOPE; info:eu-repo/grantAgreement//890702/EU/MethylRIDE: Charting DNA methylation reprogramming of Ice Age horses in the face of global climate change and extinction/MethylRIDE; cea-04286440; https://cea.hal.science/cea-04286440Test; https://cea.hal.science/cea-04286440/documentTest; https://cea.hal.science/cea-04286440/file/1-s2.0-S2589004223002213-main.pdfTest; PUBMED: 36843848; WOS: 000995047100001 |
| DOI: | 10.1016/j.isci.2023.106144 |
| الإتاحة: | https://doi.org/10.1016/j.isci.2023.106144Test https://cea.hal.science/cea-04286440Test https://cea.hal.science/cea-04286440/documentTest https://cea.hal.science/cea-04286440/file/1-s2.0-S2589004223002213-main.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2220CCA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.isci.2023.106144 |
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