دورية أكاديمية
Physician-Confirmed and Administrative Definitions of Stroke in UK Biobank Reflect the Same Underlying Genetic Trait.
| العنوان: | Physician-Confirmed and Administrative Definitions of Stroke in UK Biobank Reflect the Same Underlying Genetic Trait. |
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| المؤلفون: | Rannikmäe, Kristiina, Rawlik, Konrad, Dichgans, Martin, Tenesa, Albert, Sudlow, Cathie, Ferguson, Amy C, Avramidis, Nikos, Jiang, Muchen, Pirastu, Nicola, Shen, Xia, Davidson, Emma, Woodfield, Rebecca, Malik, Rainer |
| المصدر: | Frontiers in neurology 12, 787107 (2022). doi:10.3389/fneur.2021.787107 |
| بيانات النشر: | Frontiers Research Foundation |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, accuracy, genetic correlation, routinely collected health data, stroke, validation |
| جغرافية الموضوع: | DE |
| الوصف: | Stroke in UK Biobank (UKB) is ascertained via linkages to coded administrative datasets and self-report. We studied the accuracy of these codes using genetic validation.We compiled stroke-specific and broad cerebrovascular disease (CVD) code lists (Read V2/V3, ICD-9/-10) for medical settings (hospital, death record, primary care) and self-report. Among 408,210 UKB participants, we identified all with a relevant code, creating 12 stroke definitions based on the code type and source. We performed genome-wide association studies (GWASs) for each definition, comparing summary results against the largest published stroke GWAS (MEGASTROKE), assessing genetic correlations, and replicating 32 stroke-associated loci.The stroke case numbers identified varied widely from 3,976 (primary care stroke-specific codes) to 19,449 (all codes, all sources). All 12 UKB stroke definitions were significantly correlated with the MEGASTROKE summary GWAS results (rg.81-1) and each other (rg.4-1). However, Bonferroni-corrected confidence intervals were wide, suggesting limited precision of some results. Six previously reported stroke-associated loci were replicated using ≥1 UKB stroke definition.Stroke case numbers in UKB depend on the code source and type used, with a 5-fold difference in the maximum case-sample size. All stroke definitions are significantly genetically correlated with the largest stroke GWAS to date. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:35185750; info:eu-repo/semantics/altIdentifier/issn/1664-2295; https://pub.dzne.de/record/163433Test; https://pub.dzne.de/search?p=id:%22DZNE-2022-00193%22Test |
| الإتاحة: | https://doi.org/10.3389/fneur.2021.787107Test https://pub.dzne.de/record/163433Test https://pub.dzne.de/search?p=id:%22DZNE-2022-00193%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2218F999 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |