دورية أكاديمية
Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract
| العنوان: | Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract |
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| المؤلفون: | Bone, M. Ashley, Wilk, Aaron J., Perault, Andrew I., Marlatt, Sara A., Scheller, Erich V., Anthouard, Rebecca, Chen, Qing, Stibitz, Scott, Cotter, Peggy A., Julio, Steven M. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America, 114(8) |
| سنة النشر: | 2017 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Mice, Inbred BALB C, two-component system, Respiratory System, Bordetella bronchiseptica, gene regulation, Animals, Female, Gene Expression Regulation, Bacterial, Cell Line, Virulence, respiratory infection, Rats, Bordetella, Bacterial Proteins, Bordetella pertussis, Virulence Factors |
| الوصف: | Bordetella spp. includes Bordetella pertussis, the causal agent of whooping cough. The Bordetella virulence gene (BvgAS) two-component regulatory system (TCS) is considered the “master virulence regulator” in Bordetella, as it controls expression of all known virulence factor-encoding genes. We show here that another TCS, PlrSR, is required for BvgAS activity in the lower respiratory tract (LRT) and for virulence even when BvgAS is rendered constitutively active, suggesting that it controls critical functions for bacterial survival in the LRT independently of BvgAS. Our data introduce a new layer of complexity to a paradigm of Bordetella virulence control that has held for more than 30 y, and they indicate the existence of previously unknown bacterial factors that may serve as vaccine components and therapeutic targets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/0z4j-0z45Test; https://cdr.lib.unc.edu/downloads/bg257m50b?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/bg257m50bTest |
| DOI: | 10.17615/0z4j-0z45 |
| الإتاحة: | https://doi.org/10.17615/0z4j-0z45Test https://cdr.lib.unc.edu/downloads/bg257m50b?file=thumbnailTest https://cdr.lib.unc.edu/downloads/bg257m50bTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.2212D8FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/0z4j-0z45 |
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