دورية أكاديمية
Prevalence of HPV genital infection in patients with moderate-to-severe psoriasis undergoing systemic treatment with immunosuppressive agents or biologics
| العنوان: | Prevalence of HPV genital infection in patients with moderate-to-severe psoriasis undergoing systemic treatment with immunosuppressive agents or biologics |
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| المؤلفون: | Offidani A., Radi G., Bianchi L., Cannavo S. P., Conti A., Gesuita R., Salaffi F., Talamonti M., Campanati A. |
| المساهمون: | Offidani, A., Radi, G., Bianchi, L., Cannavo, S. P., Conti, A., Gesuita, R., Salaffi, F., Talamonti, M., Campanati, A. |
| سنة النشر: | 2021 |
| المجموعة: | Università Politecnica delle Marche: IRIS |
| مصطلحات موضوعية: | human papilloma virus (HPV), immunomodulatory or immunosuppressive therapy, psoriasi, Adult, Biological Factor, Female, Genital Diseases, Male, Human, Immunocompromised Host, Immunosuppressive Agent, Italy, Middle Aged, Papillomavirus Infection, Patient Acuity, Prevalence, Prospective Studie, Risk Factors |
| الوصف: | Background: Psoriasis is an immune-mediated inflammatory disease and its relationship with infection has been extensively investigated. Concern for the increased prevalence of human papilloma virus (HPV) infection in patients undergoing systemic immunomodulatory or immunosuppressive therapies for psoriasis has been gradually growing among clinicians. Objectives: To evaluate the prevalence of HPV in a cohort of patients with psoriasis treated with currently available systemic, conventional and biotechnological drugs. Materials & Methods: A multi-centric prospective study was conducted in the main dermatological clinical centres of central and southern Italy. Data from 588 patients (366 males and 222 females) with moderate-to-severe psoriasis, aged ≥18 years and treated with conventional and biological drugs, were collected based on a documented history of HPV infection, a positive Papanicolaou test (Pap-test) when available, and clinical evidence of genital warts reported during consultation. Results: Overall, 18 of 588 patients (3.6% [95% CI: 1.8–4.5]) were positive for HPV or had a history of cervical cancer. Considering anamnestic and demographic data, such as gender, age, smoking, weight and body mass index, no statistically significant differences between HPV+ and HPV- patients were found. Moreover, the eradication of HPV infection was successfully achieved using conventional treatments. Conclusion: The prevalence of HPV infection in patients with moderate-to-severe psoriasis, undergoing systemic treatment with immunosuppressive agents or biologics, appears to be the same as that in the general Italian population, indicating that the level of infection among such patients is acceptable. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34642139; info:eu-repo/semantics/altIdentifier/wos/WOS:000715197100007; volume:31; issue:4; firstpage:493; lastpage:498; numberofpages:6; journal:EUROPEAN JOURNAL OF DERMATOLOGY; http://hdl.handle.net/11566/299645Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118411340 |
| DOI: | 10.1684/ejd.2021.4121 |
| الإتاحة: | https://doi.org/10.1684/ejd.2021.4121Test http://hdl.handle.net/11566/299645Test |
| رقم الانضمام: | edsbas.21F8C91C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1684/ejd.2021.4121 |
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