دورية أكاديمية
MicroRNA Genes and Their Target 3 '-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers
| العنوان: | MicroRNA Genes and Their Target 3 '-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers |
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| المؤلفون: | Ryland, GL, Bearfoot, JL, Doyle, MA, Boyle, SE, Choong, DYH, Rowley, SM, Tothill, RW, Gorringe, KL, Campbell, IG |
| المساهمون: | Cooney, AJ |
| بيانات النشر: | PUBLIC LIBRARY SCIENCE |
| سنة النشر: | 2012 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation screening using massively-parallel sequencing of 712 miRNA genes in 86 ovarian cancer cases identified only 5 mutated miRNA genes, each in a different case. One mutation was located in the mature miRNA, and three mutations were predicted to alter the secondary structure of the miRNA transcript. Screening of the 3'-untranslated region of 18 candidate cancer genes identified one mutation in each of AKT2, EGFR, ERRB2 and CTNNB1. The functional effect of these mutations is unclear, as expression data available for AKT2 and EGFR showed no increase in gene transcript. Mutations in miRNA genes and 3'-untranslated regions are thus uncommon in ovarian cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | pii: PONE-D-12-02750; Ryland, G. L., Bearfoot, J. L., Doyle, M. A., Boyle, S. E., Choong, D. Y. H., Rowley, S. M., Tothill, R. W., Gorringe, K. L. & Campbell, I. G. (2012). MicroRNA Genes and Their Target 3 '-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers. PLOS ONE, 7 (4), https://doi.org/10.1371/journal.pone.0035805Test.; http://hdl.handle.net/11343/264097Test |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0035805Test http://hdl.handle.net/11343/264097Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.21E44B54 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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