التفاصيل البيبلوغرافية
| العنوان: |
Effects of Pharmacologic and Non-pharmacologic Interventions on Menopause-related Quality of Life: A Pooled Analysis of Individual Participant Data from Four MsFLASH Trials |
| المؤلفون: |
Diem, Susan J., LaCroix, Andrea Z., Reed, Susan D., Larson, Joseph C., Newton, Katherine M., Ensrud, Kristine E., Woods, Nancy F., Guthrie, Katherine A. |
| المصدر: |
Menopause |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Article, psy, socio |
| الوصف: |
OBJECTIVE: The Menopause Strategies: Finding Lasting Answers for Symptoms and Health network conducted three randomized clinical trials (RCTs) testing six interventions treating vasomotor symptoms (VMS), and also collected menopause-related quality of life (QOL) measures. A fourth RCT assessed an intervention for insomnia symptoms among women with VMS. We describe these seven interventions’ effects on menopause-related QOL relative to control in women with VMS. METHODS: We pooled individual-level data from 1005 peri- and postmenopausal women with ≥14 VMS/week across the four RCTs. Interventions included escitalopram 10–20mg/day; yoga/aerobic exercise; 1.8 g/day omega-3-fatty acids; oral 17-beta-estradiol 0.5 mg/day; venlafaxine XR 75 mg/day; and cognitive behavioral therapy for insomnia (CBT-I). Outcomes measures were the Menopause-related Quality of Life scale (MENQOL) and its subscales. RESULTS: Significant improvements in total MENQOL from baseline were observed with estradiol, escitalopram, CBT-I, and yoga, with mean decreases of 0.3 to 0.5 points relative to control. The largest improvement in the vasomotor subscale was observed with estradiol (−1.2 points), with more modest but significant effects seen with escitalopram, yoga and CBT-I. Significant improvements in the psychosocial subscale were observed for escitalopram, venlafaxine, and CBT-I. For the physical subscale, the greatest improvement was observed for CBT-I and exercise, while for the sexual subscale, the greatest improvement was observed for CBT-I, with yoga and estradiol demonstrating smaller effects. CONCLUSIONS: These results suggest that for menopause-related QOL, women have a variety of treatment strategies to choose from and can select an approach based on most bothersome symptoms and individual preferences. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034544Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034544Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.21AAA050 |
| قاعدة البيانات: |
BASE |
